3-Bromo-4-hydroxypyridine
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3-Bromo-4-hydroxypyridine ??
- ???
- 225-230℃
- ?? ?
- 338.2±22.0 °C(Predicted)
- ??
- 1.788±0.06 g/cm3(Predicted)
- ?? ??
- Inert atmosphere,Room Temperature
- ??? ??
- ??
- ?? ?? (pKa)
- 3.71±0.18(Predicted)
- ??
- ???
- CAS ??????
- 36953-41-0(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| HS ?? | 2933399990 |
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3-Bromo-4-hydroxypyridine C??? ??, ??, ??
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3-Bromo-4-hydroxypyridine is a pyrrole that can be used in cancer treatment. It inhibits the growth of cancer cells by binding to MKN-45 on the cell surface, thereby preventing it from binding to other proteins and triggering cell proliferation.Synthesis
3-Bromo-4-hydroxypyridine is synthesized from 3-bromo-5 hydroxypyridine by reacting it with ammonia or methylamine.Concentrated sulfuric acid (85.0mL) and the 3-bromo-4-aminopyridine (113.0g, 0.65mol) were added successively to the distilled water (550.0mL) at 0°C, and then NaNO2 (63.1g, 0.91mol) aqueous solution (130.0mL) was added drop-wise to maintain the temperature between 0 and 5°C. After stirring at r. t. for 1h, the reaction mixture was heated at 95°C for a further 0.5h. Upon cooling to below 0°C, the mixture was alkalized to pH 6 with saturated sodium hydroxide solution, washed with ethyl acetate (200mL×3) and brine (200mL), dried over anhydrous Na2SO4, filtered and concentrated to yield 3-Bromo-4-hydroxypyridine as a yellow solid (75.1g, 66.2percent).
3-Bromo-4-hydroxypyridine ?? ?? ? ???
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4-Amino-3-bromopyridine
3,5-DIBROMO-4-PYRIDINOL
4-??????
4-Nitropyridine N-oxide
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4-???????
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3-Bromo-4-hydroxypyridine ?? ??
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3-Bromo-4-hydroxypyridine ?? ??:
3-?????? 3-?????? 3-???? 4-??????? ??
3-BROMO-4-FLUOROPYRIDINE
1-Hexadecylpyridinium bromide
2-Chloro-3-cyanopyridine
3-BROMO-4-METHOXY-PYRIDINE
4-BROMO-2-HYDROXYPYRIDINE
3-BROMO-2-HYDROXYPYRIDINE
METHYL 5-BROMO-2-HYDROXYPYRIDINE-3-CARBOXYLATE
3,5-DIBROMO-2-HYDROXYPYRIDINE
4-BROMO-3-HYDROXYPYRIDINE
Methyl 5-Bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-4-methoxycarbonyl-2(1H)-pyridinone
5-BROMO-6-HYDROXYPYRIDINE-3-CARBOXYLIC ACID
3-Bromo-5-hydroxypyridine
2-Bromo-4-Hydroxypyridine