ChemicalBook >?? ???? >?? ???>??? ?? ?? ???>?? ??>??? ?? ??>5-Chloropyrazolo[1,5-a]pyrimidine

5-Chloropyrazolo[1,5-a]pyrimidine

5-Chloropyrazolo[1,5-a]pyrimidine ??? ???

?? ??:: 29274-24-6

???:: 5-Chloropyrazolo[1,5-a]pyrimidine

???(??):: Larotinib Impurity 2;Larotrectinib CPP Impurity;WEPRLWNMBTYGGD-UHFFFAOYSA-N;5-Chloropyrazolo[1,5-a]py...;5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE;5-chlorpyrazole [1,5-a] pyrimidine;5-Chloropyrazole [1,5-a] pyrimidine;Pyrazolo[1,5-a]pyriMidine, 5-chloro-;5-Chloropyrazolo[1,5-a]pyrimidine 97%;3-(2,5-dioxopyrrolidin-5-yl)propanoicacid

CBNumber:: CB61478196

???:: C6H4ClN3

??? ??:: 153.57

MOL ??:: 29274-24-6.mol

?? ?? 267

5-Chloropyrazolo[1,5-a]pyrimidine ??

??: 1.51±0.1 g/cm3(Predicted)

?? ??: under inert gas (nitrogen or Argon) at 2-8°C

?? ?? (pKa): -0.49±0.30(Predicted)

??: Light brown to yellow Solid

InChI: InChI=1S/C6H4ClN3/c7-5-2-4-10-6(9-5)1-3-8-10/h1-4H

InChIKey: WEPRLWNMBTYGGD-UHFFFAOYSA-N

SMILES: C12=CC=NN1C=CC(Cl)=N2

?? ? ?? ??
?? ? ???? ?? (GHS)

????(UN No.)	UN2811
?? ??	IRRITANT
HS ??	2933599590

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

5-Chloropyrazolo[1,5-a]pyrimidine C??? ??, ??, ??

??

5-Chloropyrazolo[1,5-a]pyrimidine is formed by replacing the hydrogen atom at position 5 of the pyrazolo[1,5-a]pyrimidine compound structure with a chlorine atom. It can serve as a pharmaceutical intermediate for synthesising other bioactive compounds. Pyrazolo[1,5-a]pyrimidine derivatives function as ATP-competitive and allosteric inhibitors of protein kinases, with those targeting the epidermal growth factor receptor (EGFR) demonstrating potential in the treatment of non-small cell lung cancer (NSCLC).

??

5-Chloropyrazolo[1,5-a]pyrimidine was used in the preparation of β-substituted biarylphenylalanine amides as selective amino amide dipeptidyl peptidase IV inhibitors for treatment of type 2 diabetes.

5-Chloropyrazolo[1,5-a]pyrimidine ?? ?? ? ???

???

5-BROMOPYRAZOLO[1,5-A]PYRIMIDINE ?????? 5-Hydroxypyrazolo[1,5-a]pyrimidine ??????(??)

?? ??

3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE

5-Chloropyrazolo[1,5-a]pyrimidine ?? ??

???( 267)?? ??

???	??	???	??	?? ?	??
Xiamen Yunfan Biotech Co.,Ltd.	+8618050056030	yezhaobao@yfpharm.com	China	27	58
Jinan Zhonghan Chemical Technology Co., LTD.	+undefined15066662237	3281004549@qq.com	China	291	58
SHANGHAI FLUORORING PHARMACEUTICAL CO LTD	+undefined18018698069	sales@fluororing.com	China	76	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	296	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58

5-Chloropyrazolo[1,5-a]pyrimidine ?? ??:

??? Pyrimidine Cloxacillin Sodium cloxacillin monohydrate Zolpidem tartrate Chlorzoxazone 5-chloropyrazine-2-carboxamide Pyrazinecarboxylic acid, 5-chloro-, ethyl ester 5-CHLORO-PYRIDINE-3-CARBALDEHYDE diMethyl 5-chloropyridine-2,3-dicarboxylate ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE 5-CHLOROPYRIDO[4,3-B]PYRAZINE 3-CHLORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile 5-CHLORO-2-FORMYLPYRIDINE 5-CHLOROPYRIDINE-2-BORONIC ACID PINACOL ESTER 5-Chloropyridine-2-carboxamide 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE

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