??????
|
|
?????? ??
- ???
- 240-255 °C
- ??
- 1.14 g/mL at 25 °C (lit.)
- ???
- n
20/D 1.47(lit.)
- ?? ??
- 2-8°C
- ???
- ????, ??? ????, ??? ? ?? ? ???
- ??? ??
- ??
- ??
- ???? ?? ???
- Specific Gravity
- 1.14
- ???
- ???
- ????
- 0.23 W/(m·K)
- Merck
- 14,3781
- Dielectric constant
- 2.8（Ambient）
- ??? ?? ??
- ?? ??
???
?? ???
- ??? ?? ??
- Ethyl cellulose (9004-57-3)
- InChI
- InChI=1S/C23H24N6O4/c1-4-5-8-28(9-10-33-17(3)30)20-6-7-22(16(2)11-20)26-27-23-18(14-24)12-21(29(31)32)13-19(23)15-25/h6-7,11-13H,4-5,8-10H2,1-3H3/b27-26+
- InChIKey
- ARSKJXYLLONUAJ-CYYJNZCTSA-N
- SMILES
- C(OCCN(CCCC)C1=CC=C(/N=N/C2=C(C#N)C=C([N+]([O-])=O)C=C2C#N)C(C)=C1)(=O)C
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36 | ||
| WGK ?? | 1 | ||
| RTECS ?? | FJ5950500 | ||
| F ?????? | 3 | ||
| ?? ?? ?? | 698 °F | ||
| TSCA | TSCA listed | ||
| HS ?? | 39129000 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ?? ?? ??? | 9004-57-3(Hazardous Substances Data) | ||
| ???? ?? | KE-13689 |
?????? C??? ??, ??, ??
????
? (1) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.
??(2) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 2.0ppm ????? ??.
??(3) ??? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 1.0ppm ????? ??.
??(4) ?? : ? ??? ?????? ?? ??? ?, ? ?? 1.0ppm ????? ??.
??(5) ?? : ??? ??? 10cps ??? ?? ???? 80.0～120.0%, 10cps ??? ?? ???? 90.0～110.0%??. ???? 46～48% ?? ???? ??????? ???????? ??(60 : 40)? ??? ????, ???? 46～48% ??? ???? ??????? ???????? ??(80 : 20)? ??? ???? ??? ?? ????. ? ?? 5.0g? ??? ?? 105℃?? 2?? ?? ??? ?? ??? ??? ???? ??? ??? ?? 95±0.5g? ?? ?? ?? ??? ?? ??? ??? 25±0.1℃?? ??? ????.
????
? (1) ? ??? ?, ???-1,2-??? ?????? ?? ??? ??? ???? ??? ?? ????? ??? ??? ???. ??????? ??? ????? 46～48% ???? ??????? ??????, ????, ????? ?? ????????(tetrahydrofuran)? ???, ??????? ??? ????? 46～48% ?? ? ???? ???, ???, ???, ????? ?? ????? ???.
??(2) ? ?? 5g? ???????? ??(80 : 20) 95g? ??? ???? ??? ?? ??? ?? ???. ????? ? ? ??? ??? ????? ??? ???? ?? ???? ??? ?? ???.
???
? ? ?? ? 50mg? ??? ?? ???(5mL ???? ???)? ?? ???? 65mg, ?????? 2.0mL? ?????? 2.0mL? ?? ??? ?? ? ??? ??? ??. ???? 30?? ??? ?? ???? ???? 150℃, 20?? ??? ?? ????? ??? ?? ?? 40?? ??? ? 45?? ?? ?? ? ??? ??? ?? ??? 10mg ?? ?? ??? ?????? ??. ?? ???? 65mg, ?????? 2.0mL, ??????? 2.0mL? ???? ??? ??? ?? ? ??? ??? ?? ?????? 15μL? ?? ??? ??? ??. ???? 30?? ??? ?? ?? ??? ?????? ??. ????? ???? 1μL? ?? ?????????? ???? ???? ?? ????? ??(%)? ???.
WSa : ???? ?? ??????? ?(mg)
QSa : ???? ? ??????? ????? ?? ??????? ?????
QTa : ???? ? ??????? ????? ?? ??????? ?????
????????
???????????? ? : ?????????? ???(Chromosorb WHP ?? ?? ??? ?)? 10% ???????? ?? ? ?? ?? ??? ?
???????? ?? ? : ???????(TCD) ?? ?????????(FID)
??????????? : 200℃
????? ???? : 50℃
??????????? : 200℃
??????????? : ?? ?? ??
???????????? : ??? 0.25g? ??? ?? ο-???? ??? 50mL? ??.
?????
? ? ?? 1g? ??? ?? 800±25℃?? ??? ?, ? ??? 0.4% ????? ??.
??? ??
white to slightly yellowish powder??? ??
Ethyl celluloses are low density polymers (1070–1180 kg.m–3) with solubilities depending on the degree of ethylation; usually commercial grade contains 44–48% ethoxyl functional groups. Solid masses of ethylcellulose exhibit low absorption of moisture, excellent dimensional stability and low temperature toughness and impact resistance. Chemically they are less resistant towards acids than cellulose esters but much more resistant to alkalis. They can be processed by injection molding. Because ethylcellulose is soluble in a wide variety of solvents, it provides a wide variety of varnish formulations. Benzylcelluloses yield plastics with excellent dielectric properties and chemical stability.??
ethyl cellulose is a binder, film former, and thickener. It is used in suntan gels, creams, and lotions. This is the ethyl ether of cellulose.?? ??
Ethylcellulose is prepared by treating purified cellulose (sourced from chemical-grade cotton linters and wood pulp) with an alkaline solution, followed by ethylation of the alkali cellulose with chloroethane as shown below, where R represents the cellulose radical:RONa + C2H5Cl→ROC2H5+NaCl
The manner in which the ethyl group is added to cellulose can be described by the degree of substitution (DS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethyl chloride. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is three.
?? ??
Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl.Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures.
Safety Profile
Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumesSafety
Ethylcellulose is widely used in oral and topical pharmaceutical formulations. It is also used in food products. Ethylcellulose is not metabolized following oral consumption and is therefore a noncalorific substance. Because ethylcellulose is not metabolized it is not recommended for parenteral products; parenteral use may be harmful to the kidneys.Ethylcellulose is generally regarded as a nontoxic, nonallergenic, and nonirritating material.
As ethylcellulose is not considered to be a health hazard, the WHO has not specified an acceptable daily intake. The highest reported level used in an oral product is 308.8 mg in an oral sustained release tablet.
LD50 (rabbit, skin): >5 g/kg
LD50 (rat, oral): >5 g/kg
??
Ethylcellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis, both dilute and concentrated, and to salt solutions, although it is more sensitive to acidic materials than are cellulose esters.Ethylcellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This may be prevented by the use of antioxidant and chemical additives that absorb light in the 230–340nm range.
Ethylcellulose should be stored at a temperature not exceeding 32°C (90°F) in a dry area away from all sources of heat. It should not be stored next to peroxides or other oxidizing agents.
? ???
Incompatible with paraffin wax and microcrystalline wax.Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions and tablets; topical emulsions and vaginal preparations). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.?????? ?? ?? ? ???
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?????? ?? ??
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