????
|
|
???? ??
- ???
- 302-305 °C (dec.) (lit.)
- ??
- 1.0238 (rough estimate)
- ???
- 1.5400 (estimate)
- ?? ??
- Sealed in dry,Room Temperature
- ???
- H2O: 1 M, ??, ??
- ??? ??
- ???
- ??
- ???
- ??????(pH)
- 5.0-7.5 (25℃, 1M in H2O)
- ??
- ???? ?????? ??
- ???? ??
- synthetic (organic)
- ???
- ??
- ??
- Hygroscopic
- ?? ??(λmax)
- λ: 260 nm Amax: 0.015
λ: 280 nm Amax: 0.010
- Merck
- 14,2206
- JECFA Number
- 2003
- BRN
- 3563126
- ???
- ????. ?? ???, ??? ???? ????. ??? ???? ??????.
- ??? ?? ??
- ?? ????
???
- ??? ?? ??
- Choline chloride (67-48-1)
- InChI
- 1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
- InChIKey
- SGMZJAMFUVOLNK-UHFFFAOYSA-M
- SMILES
- [Cl-].C[N+](C)(C)CCO
- LogP
- -3.70
- CAS ??????
- 67-48-1(CAS DataBase Reference)
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36 | ||
| WGK ?? | 1 | ||
| RTECS ?? | KH2975000 | ||
| F ?????? | 3-9 | ||
| ?? ?? ?? | 355°C | ||
| TSCA | TSCA listed | ||
| HS ?? | 29212900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ?? ?? ??? | 67-48-1(Hazardous Substances Data) | ||
| ?? | LD50 in rats (g/kg): 0.400 i.p.; 6.64 orally (Hartung, Cornish) | ||
| ???? ?? | KE-20909 |
???? C??? ??, ??, ??
??
?? ??.??
?? ?????, ??? & ??? ???????, ??? ???????.???
???: ? ? ??·?? ?? H335 ???? ??? ??? ? ?? ?????? ?? P261 (??·?·??·???·??·????)? ??? ????. P271 ?? ?? ??? ? ?? ???? ?????. ?? P312 ???? ??? ????(??)? ??? ????. P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????. ?? P405 ????? ?? ????? ?????. P403+P233 ??? ??? ? ?? ?? ??? ???? ?????. ?? P501 (?? ??? ??? ??? ??) ???? ??? ?????????
? (1) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 2.0ppm ????? ??.
??(2) 1, 4-??? : ? ?? 0.5g? ?????(???? ??) 0.1g? ? 10mL ??? 10?? ???? ???? ?? ?????? ?? 25mL? ?????? ??(Frit sparger)? ?? ??? ??? 50℃? ????? ????? ? ?????????? ????. ??, ? 10mL? 1,4-??? 5μg? ????? ? ??? ????? 0.1g? ?? ?? ?????? ?? ?? ??? ???? ????(10ppm ??).
??????
?????????
?????????? ? : Vorcarb 3000 ?? ?? ??? ?
?????????? : 11?
?????????? ? ?? : 250℃, 4??
?????????? ??(Cryo focus temp.) : -150℃
????????? ??(Bake temp.) ? ?? : 260℃, 10?
?????????????
?????????? ? : HP-FFAP(60m × 0.32μm) ?? ?? ??? ?
??????? ? ? : ????????(FID)
?????????? : 70℃?? 5?? ???? ? 5℃/min? ??? 180℃?? ?? ???.
????????? ?? : 220℃
????????? ?? : 250℃
??????????? ? ?? : ??, 0.9mL/min
????
? (1) ? ?? 0.5g? ? 2mL? ???, ???????? 3mL? ??? ?? ??? ???? ????????? ??.
??(2) ? ?? 0.5g? ????? 2mL? ??? ?? ???? ??? ???, ??? ???????? 5mL? ??? ???? ??? ??? ?? ???? ??. ? ??? ???? ?? ??? ??? ??? ???????? ??.
??(3) ??????? 2mL? ? ??? ???(1→100) 1mL ? ?????????(1→50) 2mL? ??? ?? ???? ??.
??????????? : ?????(6???) 2g? ?? 1mL ? ??? ?? ?? ?? ?? ??? 100mL? ??.
??(4) ? ??? ???(1→20)? ????? ? ???? ??? ????.
???
? ? ?? ? 0.3g? ??? ?? 250mL ??????? ?? ??? 50mL? ??? ????? ???? ??? ???. ?? ?? ????????, ????? 10mL ? ?????????????? 2??? ??? 0.1N ???????? ????. ???? ?? ???? ??? ???. ?? ?? ???? ???? ??.
0.1N ?????? 1mL ＝ 13.96mg C5H14ClNO
?????
? ? ?? 4g? ??? ????????? ?? ??? ?, ? ?? 0.05% ????? ??.
??? ??
White crystalline powder?? ??
Choline chloride has been used:as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
for choline standard curve generation for quantifying phospholipase D (PLD) activity
as a component of slice solution for the dissection of entorhinal-hippocampal brain slices
??
ChEBI: Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline.benefits
choleretic, lipotropic, hepatoprotectant?? ??
Choline chloride appears as white crystals. Practically neutral aqueous solution(NTP, 1992). It is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.??? ?? ??
Deliquescent. Very soluble in water.?? ???
An acidic organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.????
Choline chloride is relatively nonflammable.Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic experimentally by ingestion and subcutaneous routes. Mutation data reported. A lipotropic agent which induces the reduction in fats contained in the liver. When heated to decomposition it emits toxic fumes of Cl-, SOx and NOx. See also CHOLINE.Purification Methods
Extremely deliquescent. Check purity by AgNO3 titration or by titration of OH-base after passage through an anion-exchange column. Crystallise it from absolute EtOH, or EtOH/Et2O, dry it under vacuum and store it in a vacuum desiccator over P2O5 or Mg(ClO4)2. [Beilstein 4 IV 1443.]???? ?? ?? ? ???
???
?? ??
???? ?? ??
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