(S)-1-Boc-3-hydroxypiperidine
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(S)-1-Boc-3-hydroxypiperidine ??
- ???
- 34-40 °C
- ?? ?
- 292.3±33.0 °C(Predicted)
- ??
- 1.107±0.06 g/cm3(Predicted)
- ???
- 110 °C
- ?? ??
- Keep in dark place,Sealed in dry,Room Temperature
- ???
- ???? ?????.
- ?? ?? (pKa)
- 14.74±0.20(Predicted)
- ??? ??
- ?? ?? ??? ??
- ??
- ???? ?????
- ??? (Optical Rotation)
- [α]22/D +10.0°, c = 1 in chloroform
- InChI
- InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
- InChIKey
- UIJXHKXIOCDSEB-QMMMGPOBSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
- CAS ??????
- 143900-44-1(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36/37/39 | ||
| WGK ?? | 3 | ||
| HS ?? | 29339900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
(S)-1-Boc-3-hydroxypiperidine C??? ??, ??, ??
??
(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.??? ??
White powder??
A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.(S)-1-Boc-3-hydroxypiperidine ?? ?? ? ???
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(S)-1-Boc-3-hydroxypiperidine ?? ??
???( 614)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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(S)-1-Boc-3-hydroxypiperidine ?? ??:
??-?? ???????? ????? ???? ???? tert-????? 1-?????????,3-[4-a??-3-(4-?????)-1H-????[3,4-d]????-1-?]-,1,1-?????????,(3R)- 3-????????? ?????
(R)-1-BOC-3-HYDROXYPIPERIDINE,(R)-1-N-BOC-3-HYDROXYPIPERIDINE,(R)-N-BOC-3-HYDROXYPIPERIDINE
3-Hydroxypiperidine
Btk inhibitor 1 (R enantioMer hydrochloride)
Ibrutinib Impurity 21
N-BOC-2-HYDROXYPIPERIDINE
(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Ibrutinib Impurity 24
Ibrutinib
(S)-Ibrutinib
(S)-3-Hydroxypiperidine
Ibrutinib Dimer Impurity
Ibrutinib Impurity 28