Triprolidine hydrochloride
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Triprolidine hydrochloride ??
- ???
- 115-120°C
- ?? ??
- 2-8°C
- ???
- ???: ?? 1.5? ??1
- ??? ??
- Solid
- ??
- ???? ?????
- ???
- 20°C?? >=10g/100mL
- Merck
- 13,9817
- ???
- ?????? ?? ?????. ?? ???? ???? ????.
- InChI
- InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
- InChIKey
- WYUYEJNGHIOFOC-NWBUNABESA-N
- SMILES
- C(=C/CN1CCCC1)(\C1=NC=CC=C1)/C1C=CC(C)=CC=1.Cl
- LogP
- 4.223 (est)
- CAS ??????
- 6138-79-0(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-36/37/38 | ||
| ????? | 26-36 | ||
| WGK ?? | 3 | ||
| RTECS ?? | UT7658000 | ||
| HS ?? | 2933399090 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
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Triprolidine hydrochloride C??? ??, ??, ??
??? ??
TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.??
TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet??
TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.?? ??
Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.
??? ?? ??
Water soluble.?? ???
Triprolidine hydrochloride discolors on exposure to light.????
SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.????
Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.???? ??
Potent H 1 receptor antagonist.Triprolidine hydrochloride ?? ?? ? ???
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Triprolidine hydrochloride ?? ??
???( 180)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9996 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 |
info@afinechem.com | China | 15083 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 |
info@fortunachem.com | China | 5983 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 |
gksales1@gk-bio.com | China | 9067 | 58 |
| CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 17259 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39040 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
Triprolidine hydrochloride ?? ??:
N-??-2-????? ???????? ??? ?????? ??? ????? ??? ????????? ?????? ???? ?????
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TRANS-TRIPROLIDINE HYDROCHLORIDE
Triprolidine hydrochloride
TRIPOLIDINE
TRIPROLIDINE HYDROCHLORIDE Z-ISOMER (100 MG)