ChemicalBook >?? ???? >NPGB
NPGB
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NPGB ??
- ???
- 241-243 °C
- ?? ??
- -20°C
- ???
- formic acid: soluble 49.00-51.00mg/mL
- ??? ??
- Solid
- ??
- White to off-white
- BRN
- 8024554
- InChI
- 1S/C14H12N4O4.ClH/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21;/h1-8H,(H4,15,16,17);1H
- InChIKey
- PKSBDZOBYIKNGY-UHFFFAOYSA-N
- SMILES
- Cl[H].NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O
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| ????? | 26 | ||
| WGK ?? | 3 | ||
| F ?????? | 8-10 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Dam. 1 |
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NPGB C??? ??, ??, ??
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4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:- as a substrate for trypsin for active site titration experiments
- for pre-treating of mosquito eggs in the interplasmid transposition assay
- as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
?? ??
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.Biochem/physiol Actions
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.?? ??
[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.
NPGB ?? ?? ? ???
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NPGB ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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1986399151@qq.com | China | 9844 | 58 |
| TargetMol Chemicals Inc. | 15002134094 |
marketing@targetmol.cn | China | 29855 | 58 |
| Merck KGaA | -- |
ordercn@merckgroup.com | China | 6394 | 58 |
NPGB ?? ??:
?? ???? 4-???????? ??????
4-(Methylamino)benzoic acid
4-AMINOBENZOIC ACID HCL
4-Benzyloxyaniline hydrochloride
4-BENZYLOXYANILINE
METHYL 4-METHYLAMINOBENZOATE
1-BENZYLOXY-4-NITROBENZENE
4-NITROPHENYL BENZOATE
1-phenylguanidine
PHENYL 4-AMINOBENZOATE
N-P-TOLYL-GUANIDINE
NPGB
METHYL 4-AMINOBENZOATE HYDROCHLORIDE
N-P-TOLYL-GUANIDINE HYDROCHLORIDE
P-PHENETIDINE HYDROCHLORIDE
4-(PHENOXYMETHYL)ANILINE
4-nitrophenyl 4'-guanidinobenzoate