4-??????????
|
|
4-?????????? ??
- ???
- 148-151 °C(lit.)
- ?? ?
- 234.6°C (rough estimate)
- ??
- 1.2143 (rough estimate)
- ???
- 0.007Pa at 25℃
- ???
- 1.4945 (estimate)
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- 50g/L
- ?? ?? (pKa)
- 4.50±0.10(Predicted)
- ??? ??
- ??? ??
- ??
- ???? ??? ?? ?? ???
- ??????(pH)
- 2.0-2.4 (30g/l, H2O, 20℃)
- ???
- ????????? ???? ?????. ?? ?? ?????.
- BRN
- 1448766
- InChI
- 1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
- InChIKey
- XQXPVVBIMDBYFF-UHFFFAOYSA-N
- SMILES
- OC(=O)Cc1ccc(O)cc1
- LogP
- 0.75 at 25℃
- CAS ??????
- 156-38-7(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36-24/25 | ||
| WGK ?? | 3 | ||
| RTECS ?? | AI2680000 | ||
| ?? ?? ?? | Irritant | ||
| TSCA | TSCA listed | ||
| HS ?? | 29182990 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
4-?????????? C??? ??, ??, ??
??? ??
4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics.??
A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.?? ??
4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid.4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%.
??
ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate.???? ??
4-Hydroxyphenylacetic acid (4-HPA) is an important microbial-derived metabolite of polyphenols in the intestinal tract[4].Purification Methods
Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]4-?????????? ?? ?? ? ???
???
????
??
4-Aminophenylacetic acid
?????
??2-(4-(????)??)?????
4-Iodophenylacetic acid
2-(4-??????)???
??4-??????????
4-????????????
4-???????
2-?????-1-(4-???????)???
3,4-Dihydroxyphenylacetic acid
4-Vinylphenol
?? ??
4-?????????? ?? ??
???( 801)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Beijing CosmicKoda Chemical Technology Co.,Ltd | 8615311061293 15311061293 |
JeanWangCosmicKoda@outlook.com | China | 49 | 58 |
| Nantong Provichem Biotech Co., Ltd. | +8617505220108 |
sales@provichem.cn | China | 96 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 |
Sibel@chuanghaibio.com | China | 8737 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 |
1097@dideu.com | China | 3989 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 |
sales1@chuanghaibio.com | China | 5218 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +86-15383190639 |
admin@86-ss.com | China | 992 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 |
niki@zlchemi.com | China | 7240 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29626 | 60 |
| Dalian Richfortune Chemicals Co., Ltd | +86-86-411-84820922 +86-8613904096939 |
sales@richfortunechem.com | China | 305 | 57 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21531 | 55 |