10-Gingerol
|
|
10-Gingerol ??
- ???
- 56-58 °C
- ?? ?
- 499.7±35.0 °C(Predicted)
- ??
- 1.037±0.06 g/cm3(Predicted)
- ???
- 166℃
- ?? ??
- 2-8°C
- ???
- ???: ???5mg/mL, ??, ??
- ??? ??
- Solid
- ?? ?? (pKa)
- 10.02±0.20(Predicted)
- ??
- ???
- ???
- ?? ?? ?? ??
- ?? ??
- ????
???, ??? ?? ? ?? ??
- InChI
- InChI=1S/C21H34O4/c1-3-4-5-6-7-8-9-10-18(22)16-19(23)13-11-17-12-14-20(24)21(15-17)25-2/h12,14-15,18,22,24H,3-11,13,16H2,1-2H3/t18-/m0/s1
- InChIKey
- AIULWNKTYPZYAN-SFHVURJKSA-N
- SMILES
- C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCCCCCC
- LogP
- 4.900 (est)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ?? ???? ?? | 53 | ||
|---|---|---|---|
| ????? | 24/25 | ||
| WGK ?? | 3 | ||
| HS ?? | 29145019 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| ????(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ?? ?: | Warning | ||||||||||||||||||||||||||||
| ??·?? ??: |
|
||||||||||||||||||||||||||||
| ??????: |
|
10-Gingerol C??? ??, ??, ??
??
10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH , superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; ) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against M. avium and M. tuberculosis (MICs = 25 and 50 μg/ml, respectively). 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.??
(+)-(S)-[10]-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.Biochem/physiol Actions
[10]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity.10-Gingerol ?? ?? ? ???
???
?? ??
10-Gingerol ?? ??
???( 276)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hubei Danding Pharmaceutical Technology Co., Ltd | +86-18917019315 +86-13173601896 |
3582572959@qq.com | China | 496 | 58 |
| Lianyungang Kaiyu Environmental Tech Co., Ltd. | +86-0086-19851820538 +8619851820538 |
carlos@khonorchem.com | China | 314 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29815 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 |
sales@biopurify.com | China | 4616 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 |
52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |