?????
|
|
????? ??
- ???
- 95-98C
- ?? ?
- bp0.15 214-218°; bp1 278-281°
- ??
- 1.253
- ???
- 1.6100 (estimate)
- ?? ??
- 2-8°C
- ???
- ??? ?? ?? ???, ??????? ? ??, ????? ????(96%). ?? ?? ??? ?????.
- ??? ??
- Solid
- ?? ?? (pKa)
- pKa 7.8(H2O,t =24±1) (Uncertain)
- ??
- ???
- ???
- 28.28mg/L(24℃)
- Merck
- 14,7183
- ???
- ??? ?? ?????? 1? ?? ??????. DMSO ?? ??? ??? -20°C?? ?? 3?? ?? ??? ? ????.
- ?? ??
- ?? ??
- InChI
- InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
- InChIKey
- RGCVKNLCSQQDEP-UHFFFAOYSA-N
- SMILES
- N1(CCO)CCN(CCCN2C3=CC(Cl)=CC=C3SC3=C2C=CC=C3)CC1
- CAS ??????
- 58-39-9(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-43 | ||
| ????? | 28-36/37/39-45 | ||
| ????(UN No.) | UN 2811 6.1 / PGII | ||
| WGK ?? | 3 | ||
| RTECS ?? | TL7175000 | ||
| HS ?? | 29349990 | ||
| ???? ??? | 3 - Flammable liquids | ||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
||
| ?? ?? ??? | 58-39-9(Hazardous Substances Data) | ||
| ?? | LD50 oral in rat: 318mg/kg | ||
| ???? ?? | KE-05806 |
????? C??? ??, ??, ??
??? ??
Off-White to Pale Yellow Solid??
D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.??
ChEBI: A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.?? ??
Perphenazine, 4-[3-(2-chlorophenothiazine-10-yl)propyl]piperazineethanol; 2-chloro-10-[3-[4-(2-hydroxyethyl)piperazinyl]propyl]phenothiazine(Trilafon), is an effective antipsychotic and antiemetic.Safety Profile
Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intramuscular routes. Human systemic effects by intramuscular route: muscle spasms. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, NOx, and cl-.????? ?? ?? ? ???
???
?? ??
????? ?? ??
???( 242)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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????? ?? ??:
Perphenazine-17-N-Oxide DiHCl
Perphenazine impurity
Perphenazine-14-N-Oxide
PERPHENAZINE
Methophenazine
thiopropazate
Chlorpromazine
Prochlorperazine
2-Chlorophenothiazine
PERPHENAZINE SULFOXIDE (100 MG),Perphenazine sulfoxide
PERPHENAZINE HCL,Perphenazine hydrochloride
PERPHENAZINE-D4 (PHENOTHIAZINE-1,3,7,9-D4)
perphenazine decanoate
perphenazine enanthate
amitriptyline-perphenazine combination
PERPHENAZINE-D4
PERPHENAZINE SULPHOXIDE
Perphenazine maleate,Perphenazine dimaleate