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5-Amino-2-methylpyridine

5-Amino-2-methylpyridine ??? ???
?? ??:
3430-14-6
???:
5-Amino-2-methylpyridine
???(??):
6-Methylpyridin-3-amine;5-AMINO-2-PICOLINE;3-AMINO-6-METHYLPYRIDINE;6-METHYL-PYRIDIN-3-YLAMINE;AURORA KA-7923;5-Aminopicoline;3-AMINO-6-PICOLINE;5-Amino-2-methylpyri;6-Methyl-Pyridin-3-yl;5-Amino-2-methypyridine
CBNumber:
CB6700252
???:
C6H8N2
??? ??:
108.14
MOL ??:
3430-14-6.mol
MSDS ??:
SDS

5-Amino-2-methylpyridine ??

???
95-99°C
?? ?
238.4±20.0 °C(Predicted)
??
1.068±0.06 g/cm3(Predicted)
?? ??
Keep in dark place,Inert atmosphere,Room temperature
??? ??
??
?? ?? (pKa)
6.89±0.10(Predicted)
??
????? ???, ????
InChI
InChI=1S/C6H8N2/c1-5-2-3-6(7)4-8-5/h2-4H,7H2,1H3
InChIKey
UENBBJXGCWILBM-UHFFFAOYSA-N
SMILES
C1=NC(C)=CC=C1N
LogP
0.704
CAS ??????
3430-14-6(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn,Xi,C
?? ???? ?? 22-37/38-41-36/37/38-34-24/25
????? 26-36/39-45-36/37/39-36-27-36/37
????(UN No.) UN2811
WGK ?? 3
?? ?? ?? Harmful
?? ?? 6.1
???? III
HS ?? 29333999
???? ??? 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
????(GHS): Corrosion (GHS05)Exclamation Mark (GHS07)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? P280, P305+P351+P338, P310
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
NFPA 704
1
2 0

5-Amino-2-methylpyridine C??? ??, ??, ??

??? ??

White to orange to brown solid

??

6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.

?? ??

5-Amino-2-methylpyridine is used as a pharmaceutical intermediate for Omecamtiv Mecarbil, a selective cardiac myosin activator used to improve cardiac function.

5-Amino-2-methylpyridine ?? ?? ? ???

???

?? ??


5-Amino-2-methylpyridine ?? ??

???( 580)?? ??
??? ?? ??? ?? ?? ? ??
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5-Amino-2-methylpyridine ?? ??:

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