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Repirinast

Repirinast ??? ???
?? ??:
73080-51-0
???:
Repirinast
???(??):
Romet;MY-5116;Repirinas;REPIRINAST;Rui Pi Si Te;Repirinast (>Repirinast (>80%);Repirinast USP/EP/BP;3-Methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[5,6-c]quinoline-2-carboxylate;Isopentyl 7,8-diMethyl-4,5-dioxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-2-carboxylate
CBNumber:
CB6708874
???:
C20H21NO5
??? ??:
355.38
MOL ??:
73080-51-0.mol

Repirinast ??

???
236-241°
?? ?
488.42°C (rough estimate)
??
1.2749 (rough estimate)
???
1.6000 (estimate)
?? ??
2-8°C
???
DMSO(?? ???, ??), ???(?? ???, ??)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
10.09±0.40(Predicted)
??
???? ?????
???
1.2mg/L(??? ???? ??)

??

?? LD50 in rats, mice (mg/kg): >5000 orally, >5000 s.c. both species (Nagase)

Repirinast C??? ??, ??, ??

??

Repirinast is an orally-active antiallergic agent useful in the treatment of allergic asthma. Its activity is reportedly attributed to a metabolite, the corresponding free acid (MY-1250), which is 17 times more potent than disodium cromoglycate in inhibiting histamine release due to antigen-antibody reactions.

??

Antiallergic.

Repirinast ?? ?? ? ???

???

?? ??


Repirinast ?? ??

???( 70)?? ??
??? ?? ??? ?? ?? ? ??
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