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???????(?????)
???????(?????) ??? ???
?? ??:
115-33-3
???:
???????(?????)
???(??):
???????(?????)
???:
oxyphenisatine di(acetate)
???(??):
OXYPHENISATIN ACETATE;Isacen;Oxyphenisatin diacetate;(2-oxoindoline-3,3-diyl)bis(4,1-phenylene) dipropionate;sbfd;Levema;Fenisan;Isocrin;Isaphen;Laxocol
CBNumber:
CB6900715
???:
C24H19NO5
??? ??:
401.41
MOL ??:
115-33-3.mol

???????(?????) ??

???
244℃
?? ?
566.5±50.0 °C(Predicted)
??
1.282±0.06 g/cm3(Predicted)
?? ??
-20°C Freezer
???
?????(?? ???), DMSO(?? ???), ???????(?? ???), ???(?? ???)
?? ?? (pKa)
13.55±0.40(Predicted)
??? ??
??
??? ??
??? ??
??
???? ?????
InChI
InChI=1S/C24H19NO5/c1-15(26)29-19-11-7-17(8-12-19)24(18-9-13-20(14-10-18)30-16(2)27)21-5-3-4-6-22(21)25-23(24)28/h3-14H,1-2H3,(H,25,28)
InChIKey
PHPUXYRXPHEJDF-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2)C(C2=CC=C(OC(C)=O)C=C2)(C2=CC=C(OC(C)=O)C=C2)C1=O

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?? LD50 oral in rat: 1900mg/kg

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Laxative.

World Health Organization (WHO)

Oxyphenisatine acetate was widely used as a laxative after its cathartic activity was first described in 1925. In 1969 its use was first associated with cases of acute and chronic liver disease. This association is considered by some, but not all, national drug regulatory authorities to warrant the withdrawal from the market of preparations containing oxyphenisatine and its derivatives.

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