Naltrexone hydrochloride
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Naltrexone hydrochloride ??
- ???
- 274-2760C
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- 2-8°C
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- H2O: 50 mg/mL, ??, ??
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- powder
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- 50mg/ml? ?? ?????.
- ??
- Light Sensitive
- Merck
- 13,6389
- BRN
- 3580333
- InChIKey
- RHBRMCOKKKZVRY-LNTCFJBQNA-N
- SMILES
- O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])N(CC1CC1)CC[C@@]23C4=5)O.Cl |&1:1,6,15,24,r|
- CAS ??????
- 16676-29-2(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
Naltrexone hydrochloride C??? ??, ??, ??
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Naltrexone hydrochloride is a potent, long-acting, orally-effective narcotic antagonist useful in the management of narcotic addiction.??? ??
White Crystalline Powder??
Naltrexone hydrochloride has been used:as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model.
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model.
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22.
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Opioid antagonist.Purification Methods
This narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.]Naltrexone hydrochloride ?? ?? ? ???
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Naltrexone hydrochloride ?? ??
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Naltrexone hydrochloride ?? ??:
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