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???? ??? ???
?? ??:
2971-90-6
???:
????
???(??):
????
???:
Clopidol
???(??):
CLOPIDOLE;coyden;lerbek;WR 61112;coyden25;CLOPIDOL;Clopindol;Clopimdol;NSC 253479;CLOPIDOLUM
CBNumber:
CB7148208
???:
C7H7Cl2NO
??? ??:
192.04
MOL ??:
2971-90-6.mol

???? ??

???
>320℃
?? ?
318.4±37.0 °C(Predicted)
??
1.2494 (rough estimate)
???
1.5500 (estimate)
?? ??
Inert atmosphere,Room Temperature
???
Aqueous Base (Slightly), Methanol (Slightly, Heated)
??? ??
Solid
?? ?? (pKa)
5.50±0.33(Predicted)
??
???? ?????
???
40mg/L(??? ???? ??)
Henry's Law Constant
9.9×103 mol/(m3Pa) at 25℃, HSDB (2015)
???
???
?? ??
??? ? ???
???(???)
InChI
1S/C7H7Cl2NO/c1-3-5(8)7(11)6(9)4(2)10-3/h1-2H3,(H,10,11)
InChIKey
QCMHHYSPKNVXLR-UHFFFAOYSA-N
SMILES
Cc1nc(C)c(Cl)c(O)c1Cl
CAS ??????
2971-90-6(CAS DataBase Reference)
EPA
Clopidol (2971-90-6)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26
OEB B
OEL TWA: 10 mg/m3 (total), STEL: 20 mg/m3 (total)
WGK ?? 2
RTECS ?? UU7711500
HS ?? 29333990
???? ??? 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
?? ?? ??? 2971-90-6(Hazardous Substances Data)
?? LD50 orally in rats: 18 g/kg (Plisek)
???? ?? KE-05-0514
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

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Clopidol is a coccidiostat. It prevents mortality of chickens infected with the parasites E. tenella, E. necatrix, E. acervuline, E. mivati, E. brunetti, and E. maxima. It has antimalarial activity against P. berghei in mice and P. cynomologi in rhesus macaques. Clopidol is a potential contaminant in food poultry. Formulations containing clopidol have been used in the prevention of coccidiosis in chickens.

??? ??

Clopidol is a white to light brown powder.
Clopidol

??

GABA Cl channel agonist, antiparasitic

??

A penta-substituted pyridine derivative.

?? ??

White to light-brown, crystalline solid. Mp: 320°C. Practically insoluble in water. Administered to poultry to prevent the growth of pathogenic parasites.

?? ???

Clopidol is a non-combustible as a solid, but dust may burn rapidly or explode when mixed with air and ignited.

???

Toxic. Mutagenic effects. Questionable carcinogen. Clopyralid.

?? ?? ??

This drug is used for the prevention of coccidiosis in poultry.

Safety Profile

A nuisance dust. When heated to decomposition it emits very toxic fumes of Cland NOx.

??? ??

Those engaged in formulation, application or manufacture of this veterinary antibiotic. Used as a pharmaceutical and as feed and food additive

?? ??

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

? ???

Noncombustible solid, but dust may explode in cloud form. Contact with strong oxidizers may cause a fire or explosion hazard

??? ??

Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

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