2-???-3,12-??????-1,9-??-28-??
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2-???-3,12-??????-1,9-??-28-?? ??
- ???
- 180-182 °C
- ?? ?
- 632.9±55.0 °C(Predicted)
- ??
- 1.18
- ?? ??
- Sealed in dry,Store in freezer, under -20°C
- ???
- ≥49.2 mg/mL in DMSO; insoluble in H2O; ≥2.682 mg/mL in EtOH with gentle warming and ultrasonic
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 4.52±0.70(Predicted)
- ??
- White to yellow
- InChIKey
- TXGZJQLMVSIZEI-UQMAOPSPSA-N
- SMILES
- C1(=O)[C@@]([C@]2([C@](C)(C=C1C#N)C1[C@@]([C@]3([C@@](C(=O)C=1)([H])[C@]1([C@@](CC[C@](C1)(C)C)(C(O)=O)CC3)[H])C)(C)CC2)[H])(C)C
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
2-???-3,12-??????-1,9-??-28-?? C??? ??, ??, ??
??? ??
Tan Solid??
Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription fa ctor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.2-???-3,12-??????-1,9-??-28-?? ?? ?? ? ???
???
(4aS,6aR,6bS,12aS,14aR,14bR,Z)-Methyl 11-(hydroxyMethylene)-2,2,6a,6b,9,9,12a-heptaMethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate
(4aS,6aR,6bS,12aS,14aR,14bR)-Methyl 11-cyano-10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,12,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
218600-51-2
Bardoxolone methyl
(4aS,6aR,6bS,10R,12aS,14aR,14bR)-Methyl 10-hydroxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate
????????
(4aS,6aR,6bS,10S,12aS,14aR,14bR)-Methyl 10-acetoxy-2,2,6a,6b,9,9,12a-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4a-carboxylate
(4aS,6aR,6bS,13aS,15aR,15bR)-Methyl 2,2,6a,6b,9,9,13a-heptaMethyl-15-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,13,13a,15,15a,15b-octadecahydropiceno[2,3-d]isoxazole-4a-carboxylate
???-9(11)-?-28-??,3,12-???-,??????(9CI)
?? ??
2-???-3,12-??????-1,9-??-28-?? ?? ??
???( 150)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
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| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
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| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11680 | 58 |