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??-?????????
??-????????? ??? ???
?? ??:
70-55-3
???:
??-?????????
???(??):
??-?????????;4-MBSA;4-?????????;p-?????????;p-???????;p-?????;???????, 4-??-;???????;?????;???-4-?????;???-p-?????
???:
p-Toluenesulfonamide
???(??):
PTSA;TsNH2;4-METHYLBENZENESULFONAMIDE;4-TOLUENESULFONAMIDE;Tosylamide;p-Tosylamide;P-TOLUENESULPHONAMIDE;TOLUENE-4-SULFONAMIDE;Tosylamine;p-Toluenesulfoamide
CBNumber:
CB7330843
???:
C7H9NO2S
??? ??:
171.22
MOL ??:
70-55-3.mol
MSDS ??:
SDS

??-????????? ??

???
134-137 °C (lit.)
?? ?
221 °C (10 mmHg)
??
1.2495 (rough estimate)
?? ??
5.9 (vs air)
???
1.6100 (estimate)
???
202 °C
?? ??
Store below +30°C.
???
DMSO: ??? ? ??
?? ?? (pKa)
10.20±0.10(Predicted)
??? ??
??? ??
??
???
??
?? ??
???
0.32g/100mL(25℃)
BRN
472689
Henry's Law Constant
2.1×101 mol/(m3Pa) at 25℃, HSDB (2015)
??? ?? ??
PLASTICISER
SKIN CONDITIONING - MISCELLANEOUS
InChI
1S/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)
InChIKey
LMYRWZFENFIFIT-UHFFFAOYSA-N
SMILES
Cc1ccc(cc1)S(N)(=O)=O
LogP
0.820
CAS ??????
70-55-3(CAS DataBase Reference)
NIST
4-Methylbenzenesulfonamide(70-55-3)
EPA
p-Toluenesulfonamide (70-55-3)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi,Xn
?? ???? ?? 36-20/21/22
????? 26-36
WGK ?? 1
RTECS ?? XT5075000
TSCA TSCA listed
???? III
HS ?? 29350090
???? ??? 11 - Combustible Solids
?? ?? ??? 70-55-3(Hazardous Substances Data)
???? ?? KE-23468
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
NFPA 704
0
2 0

??-????????? MSDS


4-Methylbenzenesulfonamide

??-????????? C??? ??, ??, ??

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???? ??? ??? ??? ?? ??? ? ????.

??? ??

White leaflets. Soluble in alcohol; very slightly soluble inwater.Combustible.

??

p-Toluenesulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate.

??

ChEBI: A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4.

?? ??

p-Toluenesulfonamide undergoes FeCl3-catalyzed direct substitution reaction with benzylic and allylic alcohols.It is employed as nucleophile in tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine opening reaction.

Purification Methods

Crystallise the amide from hot water, then from EtOH or Et2O/pet ether. [Beilstein 11 H 104, 11 IV 376.]

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