??????ISOCYANIDE
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??????ISOCYANIDE ??
- ???
- 6.45°C
- ?? ?
- 173-176 °C
- ??
- 0.878 g/mL at 25 °C(lit.)
- ???
- n
20/D 1.45(lit.)
- ???
- 170 °F
- ?? ??
- Store at +2°C to +8°C.
- ??? ??
- ??
- ??
- ??? ??~?? ??
- BRN
- 3662332
- ???
- ????. ??, ???, ????, ????? ???? ????. ???.
- InChI
- InChI=1S/C7H11N/c1-8-7-5-3-2-4-6-7/h7H,2-6H2
- InChIKey
- XYZMOVWWVXBHDP-UHFFFAOYSA-N
- SMILES
- C1([N+]#[C-])CCCCC1
- CAS ??????
- 931-53-3(CAS DataBase Reference)
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- ?? ? ?? ??
| ??? ?? | Xn,T | ||
|---|---|---|---|
| ?? ???? ?? | 20/21/22-23/24/25 | ||
| ????? | 36/37-45-24/25 | ||
| ????(UN No.) | UN 2810 6.1/PG 2 | ||
| WGK ?? | 3 | ||
| F ?????? | 10-13-21 | ||
| ?? ?? | 6.1 | ||
| ???? | III | ||
| HS ?? | 29299090 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral |
??????ISOCYANIDE C??? ??, ??, ??
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colourless liquid??
Cyclohexyl Isocyanide can be used as novel arginase inhibitors to treat diseases.?? ??
CAUTION: Use a well-ventilated hood and take all precautions before using phosgene.To a flask equipped as in Preparation 3-1 is added 1.27 kg (10.0 moles) of N-cyclohexylformamide, 3.20 liters of triethylamine, and 4.50 liters of methylene chloride. The solution is stirred while phosgene is rapidly added (300-400 gm/hr) to cause vigorous refluxing. Refluxing ceases after 1.04 kg (10.2 moles) of phosgene have been added and the addition is stopped. The reaction mixture is cooled to 22-25°C, 400 gm (23.5 moles) of ammonia gas added over a period of 1-2 hr, the mixture filtered then concentrated under reduced pressure, and the residue distilled to afford 955 gm (88%), b.p. 67-72°C (14 mm Hg).
?? ??
Cyclohexyl isocyanide reacts with dimethyl acetylenedicarboxylate to give a mixture of cyclopenta[b]pyridine derivatives, azaspirononatriene derivative and the azabicyclononatriene. It reacts with dialkyl acetylenedicarboxylates to form 1:1 intermediate which on facile addition to 1-benzylisatin and tryptantrin yields highly functionalized novel unsaturated γ-spiroiminolactones.?? ??
[1] Khalili, Gholamhossein. “ChemInform Abstract: A Diastereoselective Synthesis of (Z)-3-[(Aryl)(hydroxyimino)methyl] -2-cyclohexyl-1-(cyclohexylamino)imidazo[5,1-a]isoquinolinium Chlorides from Isoquinoline, Chlorooximes, and Cyclohexyl Isocyanide.” ChemInform 47 25 (2016).[2] M. Anary‐Abbasinejad, M. Heidari, N. Shams. “One-pot synthesis of highly functionalised 1H-pyrazoles from arylcarbohydrazides, cyclohexyl isocyanide, and acetylene diesters.” Arkivoc 2012 1 (2012).
[3] Anary‐Abbasinejad, M. M. Jaafari and Mahdiyeh Talebizadeh. “One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives.” 2019. 0.
[4] Alireza Hassanabadi. “ChemInform Abstract: Use of Cyclohexyl Isocyanide in the Esterification of N-Benzoyl α-Amino Acid Derivatives.” ChemInform 43 3 (2011).
[5] A. Hassanabadi. “The use of cyclohexyl isocyanide in the esterification of N -benzoyl α-amino acids derivatives.” Journal of Chemical Research-s 18 1 (2011): 468–470.
??????ISOCYANIDE ?? ?? ? ???
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??????ISOCYANIDE ?? ??
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??????ISOCYANIDE ?? ??:
????? ?? ?? ?? ??????
3,4-Diaminobenzoic acid
Dimedone
Benzyl isocyanide
CYCLOHEXYL ISOCYANIDE
1-ADAMANTANEISOCYANIDE
4-(N-T-BUTOXYCARBONYLAMINO)CYCLOHEXYLISOCYANIDE
2-(1'-ISOCYANOCYCLOHEXYL) ACETIC ACID METHYL ESTER
ETHYL 1-ISOCYANOCYCLOHEXANECARBOXYLATE
TRANS-ETHYL-2-ISOCYANO-CYCLOHEXYLCARBOXYLATE
(S,S)-1,2-DIISOCYANOCYCLO-HEXANE
1,2-DIISOCYANOCYCLOHEXANE
Cyclohexanecarboxylic acid, 1-isocyano-, methyl ester (9CI)
CIS-ETHYL-2-ISOCYANOCYCLO-HEXYLCARBOXYLATE
BIO-FARMA BF001930
Cyclohexane, 1,4-diisocyano- (9CI)