(R)-3-????????
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(R)-3-???????? ??
- ???
- 15°C
- ?? ?
- 215-216 °C (lit.)
- ??
- 6.5 º (c=3.5% in MeOH)
- ??
- 1.078 g/mL at 20 °C (lit.)
- ???
- n
20/D 1.488(lit.)
- ???
- >230 °F
- ?? ??
- Keep in dark place,Sealed in dry,Room Temperature
- ??? ??
- ?? ??
- ?? ?? (pKa)
- 14.91±0.20(Predicted)
- Specific Gravity
- 1.048
- ??
- ??? ????? ??? ????
- ??? (Optical Rotation)
- [α]20/D +6.5°, c = 3.5 in methanol
- ???
- ?? ???? ?????.
- ??
- Air Sensitive & Hygroscopic
- BRN
- 5376132
- InChI
- 1S/C4H9NO/c6-4-1-2-5-3-4/h4-6H,1-3H2/t4-/m1/s1
- InChIKey
- JHHZLHWJQPUNKB-SCSAIBSYSA-N
- SMILES
- O[C@@H]1CCNC1
- CAS ??????
- 2799-21-5(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-37/39 | ||
| WGK ?? | 3 | ||
| F ?????? | 10-34 | ||
| ?? ?? ?? | Irritant | ||
| HS ?? | 29339900 | ||
| ???? ??? | 10 - Combustible liquids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
(R)-3-???????? C??? ??, ??, ??
??? ??
clear yellow to orange-brown viscous liquid??
(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.Purification Methods
The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.](R)-3-???????? ?? ?? ? ???
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?? ??
(R)-3-???????? ?? ??
???( 329)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 |
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