Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing
Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids.
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ChEBI: A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties.
World Health Organization (WHO)
Bufexamac, an analgesic and anti-inflammatory agent, was
introduced in 1974 for the topical treatment of a wide range of dermatoses. The
drug is widely marketed and the World Health Organization is not aware of
restrictive action having been taken elsewhere.
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Bufexamac is an arylacetic nonsteroidal anti-inflammatory
drug. It induces allergic contact dermatitis,
eczematous or erythema multiforme like type, and
even generalized eruptions like acute generalized
exanthematous pustulosis.
