ChemicalBook >?? ???? >??? ??>???>TGF- ?? / Smad>TGF-beta / Smad ???>SD-208

SD-208

SD-208 ??? ???

?? ??:: 627536-09-8

???:: SD-208

???(??):: SD-208;SCI 208;CS-2295;SD-208 10MG;SD-208 ，S7624;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;SD-208, 10 mM in DMSO;SD-208/627536-09-8/98%

CBNumber:: CB7837155

???:: C17H10ClFN6

??? ??:: 352.75

MOL ??:: 627536-09-8.mol

MSDS ??:: SDS

?? ?? 161

SD-208 ??

?? ?: 460.4±45.0 °C(Predicted)

??: 1.487

?? ??: 2-8°C

???: ? ??? DMSO: >5mg/mL

?? ?? (pKa): 4.56±0.26(Predicted)

??? ??: ??

??: ????? ?????

InChI: 1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)

InChIKey: BERLXWPRSBJFHO-UHFFFAOYSA-N

SMILES: Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	Xn
?? ???? ??	22
WGK ??	3
???? ???	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??		P264, P270, P301+P312, P330, P501

??????:

P280	????/???/???/?????? ?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

NFPA 704

	0
2		0

SD-208 C??? ??, ??, ??

??

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

???? ??

Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.

Biochem/physiol Actions

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1

SD-208 ?? ?? ? ???

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SD-208 ?? ??

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???	??	???	??	?? ?	??
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30224	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28509	58
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Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11680	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

SD-208 ?? ??:

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole 1H-INDOLE-5-CARBOXAMIDE, 97% xav-939 SB 431542 LY2109761 LY-364947 Lenalidomide Dabrafenib

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