2',5'-Dihydroxyacetophenone
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2',5'-Dihydroxyacetophenone ??
- ???
- 204-206 °C(lit.)
- ?? ?
- 234.6°C (rough estimate)
- ??
- 1.2143 (rough estimate)
- ???
- 1.4447 (estimate)
- ?? ??
- Store below +30°C.
- ???
- ???: 50mg/mL, ??
- ?? ?? (pKa)
- 9.86±0.18(Predicted)
- ??? ??
- ?? ?? ??? ??
- ??
- ????? ???-??
- ???
- ???
- BRN
- 637903
- ??? ?? ??
- ?? ????
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- InChI
- 1S/C8H8O3/c1-5(9)7-4-6(10)2-3-8(7)11/h2-4,10-11H,1H3
- InChIKey
- WLDWSGZHNBANIO-UHFFFAOYSA-N
- SMILES
- CC(=O)c1cc(O)ccc1O
- LogP
- 1.274 (est)
- CAS ??????
- 490-78-8(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 26-36 | ||
| WGK ?? | 3 | ||
| RTECS ?? | AM7700000 | ||
| ?? ?? ?? | Irritant | ||
| TSCA | TSCA listed | ||
| HS ?? | 29145000 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2',5'-Dihydroxyacetophenone C??? ??, ??, ??
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2',5'-Dihydroxyacetophenone is a natural phenolic compound that is found in many plants. It has been shown to have anti-inflammatory properties through its ability to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1 beta.??? ??
yellow to yellow-green crystals or??
2',5'-Dihydroxyacetophenone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.?? ??
Preparation by Fries rearrangement of hydroquinone diacetate,with aluminium chloride(91%) (76%)(63–77%) (55–60%)
with zinc chloride in refluxing acetic acid (quantitative yield)
with boron trifluoride etherate in benzene at reflux (65%).
?? ??
2',5'-Dihydroxyacetophenone inhibits the formation of reactive oxygen species and nitric oxide in rat neutrophils. It also has the ability to reduce oxidative stress by scavenging free radicals and inhibiting lipid peroxidation. The underlying mechanism for these effects is not fully understood but may be due to its ability to act as a substrate for matrix-assisted laser desorption ionization (MALDI). This means that it can react with protocatechuic acid molecules that are present in the sample preparation chamber, leading to polymerase chain reaction (PCR) amplification.2',5'-Dihydroxyacetophenone ?? ?? ? ???
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2',5'-Dihydroxyacetophenone ?? ??
???( 399)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 |
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stella@zetchem.com | China | 2994 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
2',5'-Dihydroxyacetophenone ?? ??:
????????? ????? 2-????????? 4'-????????? 2,3-??????-9,10-???????-1,4-?????? 1,4-???????????? 2-???-3',4'-???????????
2-Bromoacetophenone
2',4'-Dichloroacetophenone
3-Nitroacetophenone
PIPERACETAZINE (250 MG)
4'-Bromoacetophenone
3'-Hydroxyacetophenone
3-Aminoacetophenone
4-Nitroacetophenone
3,4-Dihydroxyacetophenone
2',6'-Dihydroxyacetophenone
2'-Hydroxy-5'-methoxyacetophenone