ChemicalBook >?? ???? >cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate ??? ???

?? ??:: 67914-86-7

???:: cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

???(??):: CIS-DTM;Cis-trimesylate;Itraconazole Impurity 8;Itraconazole Impurity 14;CHLOROPHYLLIN (IN PASTE );Cis-[2-(2,4-Dichlorophenyl)-2-;Itraconazole Sulfonate IMpurity;Itraconazole Dioxolonyl IMpurity;cis-2-(2,4-Dichlorophenyl)-2-(1H-1,;ITRACOZOLE HYDROXY ISOBUTYLTRIAZOLONE IMPURITY

CBNumber:: CB8282981

???:: C14H15Cl2N3O5S

??? ??:: 408.25

MOL ??:: 67914-86-7.mol

?? ?? 217

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate ??

???: 98 °C

?? ?: 615.5±65.0 °C(Predicted)

??: 1.59±0.1 g/cm3(Predicted)

?? ??: 2-8°C

???: ?????(?? ???), ???????(?? ???), ???(?? ???)

???: ?????(??), ???????(??), ???(??)? ???

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 2.94±0.12(Predicted)

??: ???? ?????

InChI: InChI=1/C14H15Cl2N3O5S/c1-25(20,21)23-6-11-5-22-14(24-11,7-19-9-17-8-18-19)12-3-2-10(15)4-13(12)16/h2-4,8-9,11H,5-7H2,1H3/t11-,14+/s3

InChIKey: QIMASXGTWQEFGS-LNBRXUOKNA-N

SMILES: C(N1N=CN=C1)[C@]1(C2C=CC(Cl)=CC=2Cl)OC[C@H](COS(=O)(=O)C)O1 |&1:6,17,r|

CAS ??????: 67914-86-7(CAS DataBase Reference)

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H301	??? ???	?? ?? ?? - ??	?? 3	??		P264, P270, P301+P310, P321, P330,P405, P501

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate C??? ??, ??, ??

??? ??

White-to-Off-White Powder

Synthesis

A preparation method for pharmaceutical intermediate cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate. The method comprises the following steps: (1) at first is raw material with the Meta Dichlorobenzene, carries out friedel-crafts reaction with bromoacetyl bromide; (2) then at heteropolyacid TiSiW 12O 40/ SiO 2Following and the glycerine condensation of catalysis; (3) with the Benzoyl chloride 99min. esterification; (4) under the catalysis of yellow soda ash, it is condensed with 1,2,4-triazole, then hydrolysed and recrystallised to yield cis-alcohol; (5) obtain product with the methylsulfonyl chloride esterification.Reaction equation is following:
Synthesis of cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate ?? ?? ? ???

???

?? ??

???? Itraconazole

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate ?? ??

???( 217)?? ??

???	??	???	??	?? ?	??
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cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate ?? ??:

??????????? ?????????? ????????? 1,3-???? ????? ??????????? Pazufloxacin mesilate Levofloxacin Methylate Pefloxacin mesylate Imatinib Itraconazole 2-(2,4-DICHLOROPHENYL)-2-(1,2,4-TRIAZOL-1-YL METHYL)-1,3-DIOXALANE-4-YL METHYL METHANE SULFONATE trans-Itraconazole N-Desalkyl Itraconazole Itraconazole Impurity 34 Butyl Itraconazole KETO ITRACONAZOLE 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-

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