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Birch-Me

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??????(Methyl salicylate)? ????? ????? ??? ?? ??? ??????? ?? - ???? ????, ???????(????)? ?? - ???? ????. ??????? ???????? ?? ?? ??? ???, ?? ??? ??? ?? ??????? ??? ??? ???? ????? ?? ???? ???? ???.

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?? ?? ??? ?? ???????? ??? Methyl salicylate? ???? ?? (Yunnan)?? ?? ? ?? ?? ? ??? ???? ?? ???. ???? ???? ?? ??? ???? ??? ?? ?????. ???, ??? ? ???. ?? ??, ?? ???, ?? ??? ? ?? ?? ?? ?? ??? ??? ??? ? ????.

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1. Methyl salicylate ??? ???, ? ?? ? ?? ????? ???? ??? ??????. ??? ? ??? ??? ? ?? ??? ???? ??? ?? ????. ??? ???? ????. ??? ??? ??? ?? ???? ? ???, ??? ???? ??? ? ????. ?????? ??? ? ????. ?? ??, ?? ? ???? ??? ? ????. 2.? ??? ???? ?? ? ?? ??? ?? ?, ?????? ?? ???? ???? ???? ?? ? ??? ?? ?? ??? ?? ???? ?? ?????. ?? ?? ????, ??? ?? ?? ???? ?? ?? ??? ?????. 3. Methyl salicylate? ???, ???, ??, ???, ?? ? ?? ? ?? ???? ????? ?? ? ????? ?????. 4. ?? ?? ? ???? ????? ???? ?? ??? ? ?? ??? ??? ??? ???? ?? ? ???? ?????. ??? ??? ??? ?? ??????. ?? ?? ? ???? ??? ?? ?? ?? ??? ?? ? ??? ? ?? ???. 6. ???? ?? ?? ? ???? ?? ????? ?? ????? ??? ?? ?? ??? 60 ℃? ???? ??? ? 1 ??? ???? ??? ???? ???? ???? ??? ??? ????. ????, ?? ????, ?????, ? ?? ? ?? ??? ?? ? ???. 7. ??? ????? 4- ?? ?? ???? ?? ?? ?? ?? ? ???. ?? ????? ?? ????? ??? ?????

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? (1) ?? : ? ??? ??? 1.180～1.185??? ??.

??(2) ??? : ? ??? ??? ? 1.535～1.538??? ??.

??(3) ?? : ? ?? 1mL? 70% ??? 7mL? ?? ?, ? ?? ????? ??.

??(4) ?? : ? ??? ??? ????? ? ?????? ?? ??? ?, 1 ????? ??. ??, ???? ??????? ????.

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? ? ?? 1mL? 10% ?????????? 25mL? ?? ?????? ??? ?? ??? ???? ??? ??? ????. ?? ?? ??? ??? ?? ?? ?? ?? ? 75mL? ?? ?? ????? ? ????? (?)? ??? ????.

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? ? ?? ? 0.9g? ??? ?? ????? ? ????? ? ?????????? ?? ????. ??, ???? ??????? ????.

0.05N ?????????? 1mL ＝ 76.08mg C₈H₈O₃

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Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester that is naturally produced by many species of plants. Some of the plants which produce it are called wintergreens, hence the common name. This compound is used as a fragrance. It is also found in liniments (rubbing ointments).

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Methyl Salicylate is the main component of wintergreen oil and occurs in small quantities in other essential oils and fruits. It is a colorless liquid with a characteristic wintergreen-like odor. May be prepared by extraction from natural sources; or by esterification of salicylic acid with methanol.

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Numerous plants produce methyl salicylate in very small amounts. Some plants, such as the following, produce more:
Some species of the genus Gaultheria in the family Ericaceae, including Gaultheria procumbens, the wintergreen or eastern teaberry;
Some species of the genus Betula in the family Betulaceae, particularly those in the subgenus Betulenta such as B. lenta, the black birch;
All species of the genus Spiraea in the family Rosaceae, also called the meadowsweets.
This compound is produced most likely as an anti-herbivore defense. If the plant is infected with herbivorous insects, the release of methyl salicylate may function as an aid in the recruitment of beneficial insects to kill the herbivorous insects.Aside from its toxicity, methyl salicylate may also be used by plants as a pheromone to warn other plants of pathogens such as tobacco mosaic virus.

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Methyl salicylate is an organic ester that is commonly produced naturally by wintergreens. Methyl salicylate is utilize as a anti-herbivore defense system in various plants that produces it. Methyl sa licylate is also used in high concentrations as a rubefacient to treat joint, muscular pain and acute pain. Methyl slicylate is also used as a flavoring agent and often used to provide fragrance to pr oducts.

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ChEBI: Methyl salicylate is a benzoate ester that is the methyl ester of salicylic acid. It has a role as a flavouring agent, a metabolite and an insect attractant. It is a benzoate ester, a member of salicylates and a methyl ester. It is functionally related to a salicylic acid.

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Methyl acetate, a novel acyl acceptor for biodiesel production has been developed, and a comparative study on Novozym 435-catalyzed transesterification of soybean oil for biodiesel production with different acyl acceptors has been studied (Noureddini et al., 2005).

Figure 1 shows the effect of the molar ratio of methanol to sunflower oil on the methyl ester yield for catalytic (3% CaO) transesterification in supercritical methanol at 523 K.

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Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens (eastern teaberry or winter green).

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Colorless yellowish or reddish liquid with odor of wintergreen.

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Insoluble in water.

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Methyl Salicylate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Birch-Me is incompatible with oxidizers. Birch-Me is also incompatible with strong bases. Birch-Me may react with iron salts.

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Toxic by ingestion; use in foods restrictedby FDA, lethal dose 30 cc in adults, 10 cc in chil-dren.

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Methyl salicylate is a highly toxic compound.The toxic symptoms in humans include nausea, vomiting, gastritis, diarrhea, respiratorystimulation, labored breathing, pulmonaryedema, convulsions, and coma. Ingestion of15 to 25 mL of this compound may befatal to humans. Application of the liquidon the skin and eyes produced severe irrita tion in rabbits. Oral, subcutaneous, or der mal administration of methyl salicylate intest animals produced specific developmen tal abnormalities affecting the eyes, ears, andcentral nervous system
Toxicity of this compound is relativelymore severe in humans than in many com mon laboratory animals. The oral LD50 values in test animals were within the range800–1300 mg/kg.

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Methyl salicylate is combustible.

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This anti-inflammatory agent is found in a wide number of ointments and can induce allergic contact dermatitis.

Safety Profile

Human poison by ingestion. Moderately toxic to humans by an unspecified route. Moderately toxic experimentally by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: flaccid paralysis without anesthesia, general anesthesia, dyspnea, nausea, vomiting, and respiratory stimulation. Experimental reproductive effects. A severe skin and eye irritant. Ingestion of relatively small amounts has caused severe poisoning and death. Combustible liquid when exposed to heat or flame; can react with oxibzing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

In pure form, methyl salicylate is toxic, especially when taken internally. A single teaspoon (5ml) of methyl salicylate contains 7g of salicylate, which is equivalent to more than twenty- three 300 mg aspirin tablets. The lowest published lethal dose is 101 mg / kg body weight in adult humans , (or 7.07 grams for a 70 - kg adult). It has proven fatal to small children in doses as small as 4 ml.[6] A seventeen-year- old cross - country runner at Notre Dame Academy on Staten Island, died in April 2007, after her body absorbed methyl salicylate through excessive use of topical muscle-pain relief products.
Most instances of human toxicity due to methyl salicylate are a result of over-application of topical analgesics, especially involving children. Some people have intentionally ingested large amounts of oil of wintergreen. Salicylate, the major metabolite of methyl salicylate, may be quantitated in blood, plasma or serum to confirm a diagnosis of poisoning in hospitalized patients or to assist in an autopsy.

Carcinogenicity

Available data suggest that methyl salicylate is not carcinogenic.

Purification Methods

Dilute the ester with Et2O, wash with saturated NaHCO3 (it may effervesce due to the presence of free acid), brine, dry MgSO4, filter, evaporate and distil it. Its solubility is 1g/1.5L of H2O. The benzoyl derivative has m 92o (b 270-280o/120mm), and the 3,5-dinitrobenzoate has m 107.5o, and the 3,5-dinitrocarbamoyl derivative has m 180-181o. [Hallas J Chem Soc 5770 1965, Beilstein 10 IV 143.]

Toxicity evaluation

Oral LD50 values (mg/kg) for mouse, rat and rabbit are 1110, 887 and 1300, respectively. Oral LD50 values for child and adult human (mg/kg) are 228 and 506, respectively. Topical methyl salicylate generally rarely causes systemic toxicity, but it can be absorbed by the skin leading to stimulation of the central nervous system respiratory center, disturbance of lipid and carbohydrate metabolism, and disturbance of intracellular respiration. Severe poisoning can lead to acute lung injury, lethargy, coma, seizures, cerebral edema, and death. In the case of salicylate intoxication, treatment includes general supportive care, purification of the gastrointestinal tract with activated charcoal in the case of ingestion of salicylic acid, and monitoring of serum salicylic acid concentration. Bicarbonate infusion or hemodialysis can be used to enhance the elimination of salicylic acid.

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