ChemicalBook >?? ???? >????
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???? ??
- ???
- 190-192°
- ??
- D +103°
- ?? ?
- 434.8±18.0 °C(Predicted)
- ??
- 1.036±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- DMSO: ~4.2mg/mL
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 15.18±0.70(Predicted)
- ??
- ???
- InChI
- InChI=1/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17,18-,19-,20+,21-,22+/s3
- InChIKey
- PGTVWKLGGCQMBR-TVQBYSQTNA-N
- SMILES
- [C@@]12([H])CC[C@@]3([H])C[C@@](O)(C)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(CC[C@@]21[H])C(=O)C |&1:0,4,7,12,14,18,23,r|
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| ????? | 22-24/25 | ||
|---|---|---|---|
| WGK ?? | 3 | ||
| RTECS ?? | TU4384700 | ||
| ???? ??? | 11 - Combustible Solids |
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Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.??
Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.?? ??
Ganaxolone (marketed as Ztalmy) is a first-in-class neuroactive steroid that acts as a positive modulator of gamma-aminobutyric acid (GABA) A receptors for the treatment of seizures associated with cyclooxygenase-dependent kinase-like 5 (CDKL5) deficiency (CDD).???? ??
Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.???? ?? ?? ? ???
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1-((2R,10S,13S,17S)-10,13-dimethylhexadecahydrospiro[cyclopenta[a]phenanthrene-3,2-oxiran]-17-yl)ethanone(WXG00316)
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5α-Pregnane-3,20-dione
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Pregnenolone
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???( 85)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hunan Yuanye Pharmaceutical Co., Ltd. | +8615857615745 |
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