?(2-????)?????
|
|
?(2-????)????? ??
- ???
- -50 °C
- ?? ?
- 386 °C (lit.)
- ??
- 0.985 g/mL at 20 °C (lit.)
- ?? ??
- >16 (vs air)
- Pour Point
- -46
- ???
- 1.2 mm Hg ( 93 °C)
- ???
- n
20/D 1.488
- ???
- 405 °F
- ?? ??
- 2-8°C
- ???
- ??? ?? ? ??? ?? ??(US EPA, 1985)
- ??? ??
- ??
- ??
- APHA: ≤10
- ??
- ?? ??, ??????.
- ???
- ??? ??
- ???
- <-60℃
- ??
- Cp(liquid): 1.8 J/(g·K), at 25℃
- Merck
- 14,2864
- BRN
- 1890696
- Henry's Law Constant
- (x 10-5 atmm3/mol): 1.1 at 25 °C (calculated, Howard, 1989)
- ?? ??
- ACGIH:TLV-TWA 0.1 mg/m3
OSHA:PEL-TWA 5 mg/m3
NIOSH:REL-TWA 5 mg/m3; REL-STEL 10 mg/m3
- Dielectric constant
- 5.1（24℃）
- ??? ?? ??
- ???
??
??
??
- InChI
- 1S/C24H38O4/c1-5-9-13-19(7-3)17-27-23(25)21-15-11-12-16-22(21)24(26)28-18-20(8-4)14-10-6-2/h11-12,15-16,19-20H,5-10,13-14,17-18H2,1-4H3
- InChIKey
- BJQHLKABXJIVAM-UHFFFAOYSA-N
- SMILES
- CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC
- LogP
- 7.5 at 20℃
- CAS ??????
- 117-81-7(CAS DataBase Reference)
- IARC
- 2B (Vol. Sup 7, 77, 101) 2013
??
- ?? ? ?? ??
| ??? ?? | T,F | ||
|---|---|---|---|
| ?? ???? ?? | 60-61-39/23/24/25-23/24/25-11 | ||
| ????? | 53-45-36/37-16 | ||
| OEB | B | ||
| OEL | TWA: 5 mg/m3, STEL: 10 mg/m3 | ||
| ????(UN No.) | UN 1230 3/PG 2 | ||
| WGK ?? | 1 | ||
| RTECS ?? | TI0350000 | ||
| ?? ?? ?? | 734 °F | ||
| TSCA | TSCA listed | ||
| ?? ?? | 9 | ||
| ???? | III | ||
| HS ?? | 29173400 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Repr. 1B | ||
| ?? ?? ??? | 117-81-7(Hazardous Substances Data) | ||
| ?? | Acute oral LD50 for guinea pigs 26 gm/kg, mice 30 gm/kg, rats 30,600 mg/kg, rabbits 34 gm/kg (quoted, RTECS, 1985). | ||
| IDLA | 5,000 mg/m3 | ||
| ???? ?? | KE-02196 | ||
| ?????? ??? | 2006-1-556 | ||
| ?????? ??? | ??1-69 | ||
| ?? ? ???? | ????: ????; ???(??)????: ??(2-????) ????? ? ?? 25% ?? ??? ??? |
?(2-????)????? C??? ??, ??, ??
??
???? ???? ?????? ??? ???? ???? ??? ??? ?? ????. ????? ????? ??? ??, ???? ?? ? ???? ????. ?? ?????? ????? ??, ???? ????? ????. Bis(2-ethylhexyl)phthalate? ??? ??? ????, ??? ??? ?? ????. ?? ???? ?????? ??? ??? ???? ??? ???.??? ??
Bis(2-ethylhexyl)phthalate is a colorless liquid with a slight odor. It is miscible with mineral oil and hexane, and soluble in most organic solvents. Bis(2-ethylhexyl)phthalate is insoluble in water (NTP, 1994a).??
Bis(2-ethylhexyl) phthalate is commonly used plasticizing agent for PVCs, which as such is a component of blood bank bags, surgical tubing, and other products including food wrappers and children’s toys.
?? ??
DEHP is commercially produced via esterification of phthalic acid anhydride and 2-ethylhexanol. Esterification is completed with an acid or metal catalyst or with no catalyst at high temperature.??
ChEBI: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.?? ??
Colorless to pale yellow oily liquid. Nearly odorless.??? ?? ??
Insoluble in water.?? ???
Bis(2-ethylhexyl) phthalate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides. Incompatible with nitrates .????
Inhalation can cause nausea and irritation of nose and throat. Contact of liquid with eyes or skin causes irritation. Ingestion can cause abdominal cramps, nausea and diarrhea.?? ??
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Experimental teratogenic data. Other experimental reproductive effects. Poison by intravenous route. Human systemic effects by ingestion: gastrointestinal tract effects. A mild skin and eye irritant. When heated to decomposition it emits acrid smoke.??? ??
Bis(2-ethylhexyl)phthalate is primarily used as one of several plasticizers in polyvinyl chloride resins used for fabricating flexible vinyl products. It has also been reported as being used as a replacement for polychlorinated biphenyls (PCBs) in dielectric fluids for electric capacitors and in vacuum pumps (NTP, 1994a; Merck, 1989). The primary stationary sources that have reported emissions of bis(2-ethylhexyl)phthalate in California are furniture and fixtures manufacturing, and lumber and wood products manufacturing (ARB, 1997b).Carcinogenicity
Di(2-ethylhexyl) phthalate (DEHP) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.?? ??
Bis(2-ethylhexyl) phthalate is metabolized in fish by enzymatic hydrolysis to mono-2-ethylhexyl phthalate, phthalic acid, and glucuronides of these compounds (Stalling et al., 1973).Purification Methods
Wash the ester with Na2CO3 solution, then shake it with water. After the resulting emulsion has been broken by adding ether, the ethereal solution is washed twice with water, dried (CaCl2), and evaporated. The residual liquid is distilled several times under reduced pressure, then stored in a vacuum desiccator over P2O5 [French & Singer J Chem Soc 1424 1956]. [Beilstein 9 IV 3184.]?(2-????)????? ?? ?? ? ???
???
2-??-1-???
P-????? ?
Metatitanic acid
1-???
????(II)
Esterification solution
?? ?
?????
Phthalate plasticizer
??
?????(??)
1,2-???????? ?? 2-???? ???
PHTHALIC ACID MONO-2-ETHYLHEXYL ESTER
n-???
?????????
?? ??
?(2-????)????? ?? ??
???( 831)?? ??
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?(2-????)????? ?? ??:
?-n-??????? ??? ?? ? ? ???? ????? 1,2-???????? ?? 2-???? ??? ???????? ? ??(2-????) ???? ??(2-?????) ????? ?????? ????(C4~11) ?(2-????)?????
N-Phthaloylglycine
Dibutyl phthalate
Diethyl phthalate
Dimethyl phthalate
Diallyl phthalate
Potassium hydrogen phthalate
DI-N-HEXYL PHTHALATE
Benzyl butyl phthalate
DIPHENYL PHTHALATE