??????(ALOGLIPTINE,ALOGLIPTINA)
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??????(ALOGLIPTINE,ALOGLIPTINA) ??
- ???
- 127 - 129°C
- ?? ?
- 519.2±60.0 °C(Predicted)
- ??
- 1.342
- ???
- 267.8℃
- ?? ??
- Refrigerator
- ???
- ?????(?? ???), ???????(?? ???), ???(?? ???)
- ???
- ?????(??), ???????(??), ???(??)? ???
- ?? ?? (pKa)
- 9.89±0.20(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?????
- InChI
- InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1
- InChIKey
- ZSBOMTDTBDDKMP-OAHLLOKOSA-N
- SMILES
- C(#N)C1=CC=CC=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????? | 24/25 | ||
|---|---|---|---|
| ????(UN No.) | 3077 | ||
| HS ?? | 29335990 | ||
| ?? ?? ??? | 850649-61-5(Hazardous Substances Data) |
| ????(GHS): |
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??????(ALOGLIPTINE,ALOGLIPTINA) C??? ??, ??, ??
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Alogliptin is a dipeptidyl-peptidase IV (DPP-4) inhibitor that was approved in Japan in 2010 for treatment of type 2 diabetes, a disease in which insulin resistance and β-cell dysfunction lead to hyperglycemia. As islet function is lost, the severity of insulin resistance increases. The introduction of DPP-4 inhibitors has brought a novel class of insulinotropic agents for the treatment options available to type 2 diabetic patients. The therapeutic potential of glucagon-like peptide 1 (GLP-1), an incretin peptide, for the treatment of type 2 diabetes was realized in the 1990s. The insulinotropic effects of GLP-1 depend closely on glucose concentrations providing the possibility of glucose normalization without the risk of hypoglycemia. GLP-1 has other non-insulinotropic physiological actions that are advantageous. It suppresses glucagon secretion from a cells and slows gastric emptying, which contributes to satiety and to a slower passage and reabsorption of carbohydrates. GLP-1 also contributes to satiety via a central mechanism as a neurotransmitter with effects on the hypothalamus.??? ??
White Solid??
Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.??
ChEBI: A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of t pe 2 diabetes.??????(ALOGLIPTINE,ALOGLIPTINA) ?? ?? ? ???
???
2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile
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????????? ?
?? ??
??????(ALOGLIPTINE,ALOGLIPTINA) ?? ??
???( 285)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 |
Sibel@chuanghaibio.com | China | 8738 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 |
sales2@runyanpharma.com | China | 302 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21586 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29815 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1319 | 58 |
??????(ALOGLIPTINE,ALOGLIPTINA) ?? ??:
(R)-1-??-3-N-BOC-???????
Alogliptin Related Compound 26
Benzonitrile, 2-[(tetrahydro-3-Methyl-2,4,6-trioxo-1(2H)-pyriMidinyl)Methyl]-
2,4(1H,3H)-Pyrimidinedione, 6-methoxy-3-methyl-
(S)-Alogliptin Benzoate Salt
Alogliptin iMpurity
AGOMELATINE
Linagliptin
Alogliptin benzoate
Trelagliptin
Vonoprazan fumarate
Trelagliptin succinate
Teneligliptin Hydrobromide
Tozasertib
Telmisartan
Atazanavir sulfate
Erteberel (LY500307)
Rapamycin