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????? ??? ???
?? ??:
11021-66-2
???:
?????
???(??):
?????
???:
Ristocetin
???(??):
Ristomycin A;Ristocetin, RistoMycin III, Spontin, Riston
CBNumber:
CB91179667
???:
C95H110N8O44
??? ??:
2067.92
MOL ??:
11021-66-2.mol

????? ??

??
D -120 to -133° (water)
??
1.76±0.1 g/cm3(Predicted)
?? ?? (pKa)
8.55±0.70(Predicted)

??

????(UN No.) 3249
?? ?? 6.1(b)
???? III
?? mouse,LD50,intravenous,1350mg/kg (1350mg/kg),SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE,"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 568, 1967.

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Ristocetin A sulfate is a potent antibacterial glycopeptide antibiotic that was withdrawn from clinical use following a high incidence of thrombocytopenia. Further investigation found that ristocetin A induced platelet aggregation by binding to a factor absent in people suffering from von Willebrand's disease, leading to the use of ristocetin A as an important diagnostic aid.

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