ChemicalBook >?? ???? >API>??? ??>? ????>Terazosin hydrochloride

Terazosin hydrochloride

Terazosin hydrochloride ??? ???

?? ??:: 63074-08-8

???:: Terazosin hydrochloride

???(??):: Itrin;HYTRIN;Hitrin;Vicard;Blavin;Dysalfa;Flotrin;Heitrin;Hytrine;Olyster

CBNumber:: CB9285510

???:: C19H26ClN5O4

??? ??:: 423.9

MOL ??:: 63074-08-8.mol

MSDS ??:: SDS

?? ?? 283

Terazosin hydrochloride ??

???: 261-263°C

?? ??: Inert atmosphere,2-8°C

???: H₂O: 25 mg/mL

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???: 20mg/ml? ?? ?????. ????? ????? ?????.

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InChI: InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H

InChIKey: IWSWDOUXSCRCKW-UHFFFAOYSA-N

SMILES: NC1=NC(N2CCN(C(C3OCCC3)=O)CC2)=NC2=CC(OC)=C(OC)C=C12.Cl

CAS ??????: 63074-08-8(CAS DataBase Reference)

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?? ? ???? ?? (GHS)

??? ??	Xn,Xi
?? ???? ??	22-36/37/38
?????	26-36
WGK ??	3
RTECS ??	TK8044925
???? ???	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

????(GHS):

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Warning

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??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??		P264, P270, P301+P312, P330, P501

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P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
2		0

Terazosin hydrochloride C??? ??, ??, ??

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Terazosin hydrochloride is a highly water-soluble antihypertensive agent with a structure and profile closely related to that of prazosin.

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Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies⁵. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods⁶.

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Terazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride (Hytrin), is a structuralcongener of prazosin hydrochloride. It possessessimilar selective properties of specifically inhibiting 1-adrenergic receptors. The drug is slightly less potent thanprazosin hydrochloride. Terazosin hydrochloride has a halflifeof approximately 12 hours, which is much longer thanthat of prazosin. This lends itself to a once-daily dose tocontrol hypertension in many patients.

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α 1 - and α 2B -adrenoceptor antagonist (K i values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α 1A , α 1B , α 1D , α 2B , α 2A and α 2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo .

Terazosin hydrochloride ?? ?? ? ???

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Terazosin

Terazosin hydrochloride ?? ??

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Terazosin hydrochloride ?? ??:

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Terazosin hydrochloride

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