6-Aminonicotinic acid
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6-Aminonicotinic acid ??
- ???
- >300 °C (lit.)
- ?? ?
- 253.51°C (rough estimate)
- ??
- 1.3471 (rough estimate)
- ???
- 1.5100 (estimate)
- ?? ??
- Keep in dark place,Inert atmosphere,Room temperature
- ??? ??
- ??
- ?? ?? (pKa)
- 2.86±0.10(Predicted)
- ??
- ???? ????
- ???
- ? 1.0g/L(20℃)
- Merck
- 14,456
- BRN
- 115992
- InChI
- InChI=1S/C6H6N2O2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H2,7,8)(H,9,10)
- InChIKey
- ZCIFWRHIEBXBOY-UHFFFAOYSA-N
- SMILES
- C1=NC(N)=CC=C1C(O)=O
- CAS ??????
- 3167-49-5(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi,T | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-23/24/25 | ||
| ????? | 22-24/25-45-36/37/39-26 | ||
| WGK ?? | 3 | ||
| TSCA | TSCA listed | ||
| ?? ?? | IRRITANT | ||
| HS ?? | 29333990 | ||
| ???? ??? | 11 - Combustible Solids |
6-Aminonicotinic acid C??? ??, ??, ??
??? ??
Light yellow Cryst??
6-Aminopyridine-3-carboxylic acid (6-Aminonicotinic acid) was used in the preparation of resin-bound 2-aminoazine.?? ??
6-Aminonicotinic acid is an inhibitor of bacterial DNA gyrase and topoisomerase IV. It has been shown to inhibit the growth of a number of bacteria, including E. coli K-12, with potent inhibitory activity against these enzymes. It binds to the active sites on these enzymes and prevents them from working. The detection time for 6-aminonicotinic acid is about 3 hours after exposure. It has been shown to be more potent than other inhibitors of bacterial DNA gyrase and topoisomerase IV such as 2,4-diaminopyrimidine (2,4DAP).??
ChEBI: An aminonicotinic acid in which the amino group is situated at position 6 of the pyridine ring.?? ??
Electrosynthesis of 6-aminopyridine-3-carboxylic acid (6-aminonicotinic acid) by electrochemical reduction of 2-amino-5-bromo and 2-amino-5-chloropyridine in the presence of CO2 at silver electrode has been reported.Synthesis
Using 2-amino-5-methylpyridine as the starting material, it was first reacted with triethylamine and acetyl chloride in dichloromethane at 30 °C for 5 h; the product was washed with water, dried and concentrated to obtain 2-acetamido-5-methylpyridine with a yield of 90%. Then, it was reacted with 30% hydrogen peroxide at 85 °C for 16 h under the catalysis of sodium dodecylbenzene sulfonate and γ-aluminum oxide; the product was washed with water, suction-filtered and dried to obtain 6-acetamidonicotinic acid with a yield of 91%. Finally, it was reacted with aqueous sodium hydroxide solution at 80 °C for 12 h, the pH was adjusted to 3 with 6 M hydrochloric acid, and the resulting solid was suction-filtered and dried to obtain 6-aminonicotinic acid with a yield of 92%.Purification Methods
Crystallise the acid from aqueous acetic acid. Dry it in vacuo at 70o. [Beilstein 22 III/IV 6726.]6-Aminonicotinic acid ?? ?? ? ???
???
2-Amino-5-methylpyridine
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4-??????????
2-Amino-5-cyanopyridine
5-Chloro-2-nitropyridine
2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID
??6-?????????
???????-1-????
Ethyl 6-aminonicotinate
6-Aminopyridine-3-carboxamide
6-Chloronicotinamide
?? ??
6-Aminonicotinic acid ?? ??
???( 495)?? ??
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6-Aminonicotinic acid ?? ??:
2-???????? ? ?????? ??(III) 2,5-????????? ??????? ???? 2-?????? ???? 3-?????? ??? ????????? 4-??????????
Aminopyrine
Glucosamine
2-chloro-5-cyanopyridine
5,6-Dichloronicotinic acid
4-AMINONICOTINIC ACID,4-AMINONICOTINIC ACID, 98.5%,4-Aminonicotinic acid 99%
2-Aminonicotinic acid
5-Aminonicotinic acid
Methyl 6-aminonicotinate