(8β)-10-???-1,6-???????-8-???-5-???-3-?????? ????
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(8β)-10-???-1,6-???????-8-???-5-???-3-?????? ???? ??
- ???
- 136-138°
- ?? ?
- 594.4±50.0 °C(Predicted)
- ??
- 1.3558 (rough estimate)
- ???
- 1.6200 (estimate)
- ?? ??
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- ???
- ??? ?? ?? ???, ??????? ? ??, ????? ????(96%).
- ??? ??
- Solid
- ?? ?? (pKa)
- 6.33±0.40(Predicted)
- ??
- ???? ?????
- ???
- ???, ?????, ???? ?????. ?? ???.
- Merck
- 14,9496
- ?? ??
- forensics and toxicology
pharmaceutical (small molecule)
veterinary
- InChIKey
- YSEXMKHXIOCEJA-AQDCORRGNA-N
- SMILES
- O([C@]12C[C@@H](COC(C3=CN=CC(Br)=C3)=O)CN(C)[C@]1([H])CC1=CN(C)C3=CC=CC2=C13)C |&1:1,3,18,r|
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
(8β)-10-???-1,6-???????-8-???-5-???-3-?????? ???? MSDS
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
(8β)-10-???-1,6-???????-8-???-5-???-3-?????? ???? C??? ??, ??, ??
??? ??
Fine to granular, white or yellowish powder.??
Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.???? ??
α -adrenergic, vasodilator. Cognitive enhancer.Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. A vasodilator. When heated to decomposition it emits very toxic fumes of Brand NOx.(8β)-10-???-1,6-???????-8-???-5-???-3-?????? ???? ?? ?? ? ???
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(8β)-10-???-1,6-???????-8-???-5-???-3-?????? ???? ?? ??
???( 419)?? ??
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