廣藿香酮
| 中文名稱 | 廣藿香酮 |
|---|---|
| 中文同義詞 | 4-羥基-6-甲基-3-(4-甲基-1-氧代戊基)-2H-吡喃-2-酮;廣霍香酮(廣藿香酮);廣藿香酮(標(biāo)準(zhǔn)品);POGOSTONE 廣藿香酮;廣霍香酮;廣藿香酮(分析標(biāo)準(zhǔn)品);異香附酮;廣藿香酮對(duì)照品 |
| 英文名稱 | DHELWANGIN |
| 英文同義詞 | DHELWANGIN;4-Hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one;4-Hydroxy-6-methyl-3-(4-methylpentanoyl)-2H-pyran-2-one;2H-Pyran-2-one,4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-;Autophagy,Apoptosis,Inhibitor,Pogostone,Bacterial,gram positive,gram negative,inhibit,corynebacterium xerosis;Pogostone, 10 mM in DMSO;patchoulenone |
| CAS號(hào) | 23800-56-8 |
| 分子式 | C12H16O4 |
| 分子量 | 224.25 |
| EINECS號(hào) | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品;中藥對(duì)照品;對(duì)照品;分析試劑標(biāo)準(zhǔn)品;對(duì)照品-中藥對(duì)照品;其它酚類;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品，對(duì)照品;醫(yī)藥、農(nóng)藥及染料中間體 |
| Mol文件 | 23800-56-8.mol |
| 結(jié)構(gòu)式 |  |
廣藿香酮 性質(zhì)
| 沸點(diǎn) | 348.2±42.0℃ (760 Torr) |
|---|---|
| 密度 | 1.185±0.06 g/cm3 (20 ºC 760 Torr) |
| 閃點(diǎn) | 129.9±21.4℃ |
| 儲(chǔ)存條件 | 4°C, protect from light |
| 溶解度 | DMF：1.6mg/mL；二甲基亞砜：3mg/mL；乙醇：3mg/mL；乙醇:PBS (pH 7.2) (1:5): 0.16mg/mL |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 5.27±0.50(Predicted) |
| 顏色 | 白色至米白色 |
| InChI | InChI=1S/C12H16O4/c1-7(2)4-5-9(13)11-10(14)6-8(3)16-12(11)15/h6-7,14H,4-5H2,1-3H3 |
| InChIKey | AJFJTORMMHWKFW-UHFFFAOYSA-N |
| SMILES | C1(=O)OC(C)=CC(O)=C1C(=O)CCC(C)C |
| LogP | 0.750 (est) |
IC50: apoptosis; autophagy; bacteria
Pogostone?shows inhibitory effects on HCT116 cell with an IC 50 value of 18.7±1.93 μg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC 50 : 95.13±19.44 μg/ml) and endothelial cell HUVEC (IC 50 : 112±20.77 μg/ml).
Pogostone?( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-N1416R | 廣藿香酮 Pogostone (Standard) | 23800-56-8 | 5 mg | 945元 |
| 2026/06/05 | HY-N1416R | 廣藿香酮 Pogostone (Standard) | 23800-56-8 | 10 mg | 1521元 |