2,6,3',5'-四羥基二苯乙烯
| 中文名稱 | 2,6,3',5'-四羥基二苯乙烯 |
|---|---|
| 中文同義詞 | 2,6,3',5'-四羥基二苯乙烯;買麻藤醇;(E)-2-(3,5-二羥基苯乙烯基)苯-1,3-二酚;買麻藤醇,10 MM DMSO 溶液 |
| 英文名稱 | 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol |
| 英文同義詞 | 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;-2-(3,5-Dihydroxystyryl);2-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol;Gnetol>(E)-2-(3,5-Dihydroxystyryl)benzene-1,3-diol;1,3-Benzenediol, 2-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-;2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol USP/EP/BP;TGF-β,antidiabetic,Cyclooxygenase,anticancer,HDAC,antiproliferative,antinociceptive,Inhibitor,COX,Gnetol,melanin,PPARα,antihepatotoxic,Histone deacetylases,Tyrosinase,Antioxidant,hepatoprotective,inhibit |
| CAS號 | 86361-55-9 |
| 分子式 | C14H12O4 |
| 分子量 | 244.24 |
| EINECS號 | 617-839-9 |
| 相關(guān)類別 | 植物提取物;醇;中藥對照品;其它酚類;標準品 -中藥標準品;對照品;標準品，對照品;標準品-對照品 |
| Mol文件 | 86361-55-9.mol |
| 結(jié)構(gòu)式 |  |
2,6,3',5'-四羥基二苯乙烯 性質(zhì)
| 熔點 | 271°C(lit.) |
|---|---|
| 沸點 | 540.8±30.0 °C(Predicted) |
| 密度 | 1.468±0.06 g/cm3(Predicted) |
| 儲存條件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形態(tài) | 粉末晶體 |
| 酸度系數(shù)(pKa) | 9.06±0.40(Predicted) |
| 顏色 | 白色至淺黃色至淺橙色 |
| 最大波長(λmax) | 337nm(EtOH)(lit.) |
| CAS 數(shù)據(jù)庫 | 86361-55-9 |
|
COX-1 0.78 μM (IC 50 ) |
Tyrosinase 4.5 μM (IC 50 ) |
HDAC
|
The antiproliferative activities of Gnetol are tested in HCT-116, Hep-G2, MDA-MB-231, and PC-3 cell lines by measuring cell viability after treatment with 4.1 μM, 40.9 μM, 204.7 μM, 409.4 μM, and 1023.6 μM. Gnetol shows concentration-dependent reductions in cell viability in cancer cell lines with greatest activity in colorectal cancer.
Gnetol at 200 μg/mL significantly offers the highest protection of 54.3% against the toxicant. A lower dose of Gnetol (50 μg/mL) also shields the cell line from the toxic effects of CCl4.
The ligand molecule TGF-β and PPARα protein show that Gnetol has the binding affinity of 7.0 and 8.4, respectively.
Male Sprague-Dawley rats were cannulated and dosed either intravenously with Gnetol (10?μg/kg) or orally (100?mg/kg). After oral and intravenous administration, Gnetol is detected in both serum and urine as the parent compound and as a glucuronidated metabolite. The bioavailability of Gnetol is determined to be 6%. Gnetol is rapidly glucuronidated and is excreted in urine and via nonrenal routes.
Pretreatment of Male NIH Swiss mice (20-35 g) with Gnetol (50mg/kg, SC) is able to increase the latency period to response in analgesia models.
安全信息
| 海關(guān)編碼 | 2907.29.9000 |
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/06 | G0371 | 買麻藤醇 Gnetol | 86361-55-9 | 100mg | 1850元 |
| 2026/06/05 | HY-126052 | 2,6,3',5'-四羥基二苯乙烯 Gnetol | 86361-55-9 | 1 mg | 900元 |