萘啶酮酸鈉
| 中文名稱 | 萘啶酮酸鈉 |
|---|---|
| 中文同義詞 | 萘啶酮酸鈉鹽;萘啶酮酸鈉(萘啶酸鈉鹽、1-乙基-1,4-二氫-7-甲基-4-氧代-1,8-萘啶-3-羧酸鈉鹽、萘啶酮酸鈉鹽);1-乙基-1,4-二氫-7-甲基-4-氧代-1,8-萘啶-3-羧酸鈉鹽;萘啶酮酸鈉;萘啶酸鈉鹽;1-乙基-7-甲基-4-氧代-1,4-二氫-1,8-二氮雜萘-3-羧酸鈉鹽 |
| 英文名稱 | Nalidixic acid sodium salt |
| 英文同義詞 | NALIDIXIC ACID SODIUM SALT;1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicacidsodium;8-naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-sodiu;1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID SODIUM SALT;nalidixatesodium;sodiumnalidixate;sodiumnilixalate;sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate |
| CAS號(hào) | 3374-05-8 |
| 分子式 | C12H13N2NaO3 |
| 分子量 | 256.24 |
| EINECS號(hào) | 222-159-7 |
| 相關(guān)類(lèi)別 | 合成;小分子抑制劑;中間體;有機(jī)化工原料;CEBESINE;antibiotic |
| Mol文件 | 3374-05-8.mol |
| 結(jié)構(gòu)式 |  |
萘啶酮酸鈉 性質(zhì)
| 熔點(diǎn) | >280℃ |
|---|---|
| 儲(chǔ)存條件 | Inert atmosphere,Room Temperature |
| 溶解度 | H2O：50 mg/mL，清澈，淡黃色 |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Soluble at 50mg/ml in water |
| BRN | 3580062 |
| InChI | InChI=1S/C12H12N2O3.Na.H/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;;/h4-6H,3H2,1-2H3,(H,16,17);; |
| InChIKey | XVRRVENPZKMSNF-UHFFFAOYSA-N |
| SMILES | C(N1C=C(C(=O)O)C(=O)C2=CC=C(C)N=C12)C.[NaH] |
| CAS 數(shù)據(jù)庫(kù) | 3374-05-8(CAS DataBase Reference) |
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Topoisomerase
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Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli , Pasteurella spp. , Klebsiella pneuiiioniae , Aerobacter aeroyenes , Proteus spp. , Salmonella spp. , Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively.
The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli , A. aerobacter , Proteus mirabilis , Shigella fkxneri , the ED 50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively. The acute toxicity (LD 50 ) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg.
安全信息
| 危險(xiǎn)品標(biāo)志 | Xn |
|---|---|
| 危險(xiǎn)類(lèi)別碼 | 42/43 |
| 安全說(shuō)明 | 22-36/37-45 |
| WGK Germany | - |
| RTECS號(hào) | QN2885500 |
| F | 8-10 |
| 海關(guān)編碼 | 29339900 |
| 存儲(chǔ)類(lèi)別 | 11 - 可燃固體 |
| 危險(xiǎn)性類(lèi)別 | 急性毒性 類(lèi)別4 經(jīng)口 生殖毒性 類(lèi)別2 呼吸道致敏物 類(lèi)別1 皮膚致敏物 類(lèi)別1 |
| 提供商 | 語(yǔ)言 |
|---|---|
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英文
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