N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
| 中文名稱 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 |
|---|---|
| 中文同義詞 | N-(4-碘苯基)-5-硝基-2-呋喃甲酰胺;化合物C-176;N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺;C-176, STING 抑制劑;STING抑制劑,C-176;化合物C-176,10 MM DMSO 溶液 |
| 英文名稱 | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide |
| 英文同義詞 | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;C-176 STING inhibitor;STING inhibitor 1;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;N-(4-iodophenyl)-5-nitro-2-furamide;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA;C-176, 10 mM in DMSO;C-176 |
| CAS號(hào) | 314054-00-7 |
| 分子式 | C11H7IN2O4 |
| 分子量 | 358.09 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 314054-00-7.mol |
| 結(jié)構(gòu)式 |  |
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 性質(zhì)
| 沸點(diǎn) | 361.2±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.935±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C(protect from light) |
| 溶解度 | 溶于DMSO（高達(dá)25mg/ml） |
| 酸度系數(shù)(pKa) | 11.14±0.70(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 棕色或黃色 |
| 穩(wěn)定性 | 可在-20°C的DMSO中的溶液下儲(chǔ)存長(zhǎng)達(dá)3個(gè)月。 |
| InChI | 1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15) |
| InChIKey | JBIKQXOZLBLMKI-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC=C(I)C=C1)C2=CC=C([N+]([O-])=O)O2 |
STING inhibitor C-176是一種有效的STING抑制劑。STING是細(xì)胞內(nèi)DNA感應(yīng)通路的主要信號(hào)分子。
| Target | Value |
|
STING
() |
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1
?/?
mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1
?/?
mice.
| Animal Model: | WT type mice. |
| Dosage: | 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). |
| Administration: | Intraperitoneally, once. |
| Result: | Significantly reduced Serum levels of type I IFNs and IL-6. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-112906 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 C-176 | 314054-00-7 | 5mg | 1000元 |
| 2026/06/05 | HY-112906 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 C-176 | 314054-00-7 | 10mM * 1mLin DMSO | 1100元 |