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| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Basic information |
| Product Name: | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide | | Synonyms: | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;C-176 STING inhibitor;STING inhibitor 1;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;N-(4-iodophenyl)-5-nitro-2-furamide;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA;C-176, 10 mM in DMSO;C-176 | | CAS: | 314054-00-7 | | MF: | C11H7IN2O4 | | MW: | 358.09 | | EINECS: | | | Product Categories: | | | Mol File: | 314054-00-7.mol |  |
| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Chemical Properties |
| Boiling point | 361.2±37.0 °C(Predicted) | | density | 1.935±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in DMSO (up to 25 mg/ml) | | pka | 11.14±0.70(Predicted) | | form | solid | | color | Brown or yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChI | 1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15) | | InChIKey | JBIKQXOZLBLMKI-UHFFFAOYSA-N | | SMILES | O=C(NC1=CC=C(I)C=C1)C2=CC=C([N+]([O-])=O)O2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Usage And Synthesis |
| Description | C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activationviablockade of palmitoylation at Cys91. Treatment of Trex-/-mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation. | | Uses | C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2]. | | in vivo | C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity[1].
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1 / mice[1].
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1 / mice[1].
| Animal Model: | WT type mice. | | Dosage: | 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). | | Administration: | Intraperitoneally, once. | | Result: | Significantly reduced Serum levels of type I IFNs and IL-6. |
| | storage | Store at -20°C | | References | [1] SIMONE M. HAAG. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018, 559 7713: 269-273. DOI:10.1038/s41586-018-0287-8 |
| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Preparation Products And Raw materials |
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