化合物 PNU-176798
| 中文名稱 | 化合物 PNU-176798 |
|---|---|
| 中文同義詞 | 化合物 T12509;化合物 PNU-176798 |
| 英文名稱 | PNU-176798 |
| 英文同義詞 | PNU-176798;Acetamide, N-[[(5S)-3-[4-(5-cyano-2-thiazolyl)-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]-;PNU176798,PNU 176798 |
| CAS號 | 428861-91-0 |
| 分子式 | C16H13FN4O3S |
| 分子量 | 360.36 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 428861-91-0.mol |
| 結(jié)構(gòu)式 |  |
化合物 PNU-176798 性質(zhì)
| 密度 | 1.49±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 15.53±0.46(Predicted) |
PNU-176798 是一種抗菌劑，能夠作用于大多數(shù)革蘭氏陽性菌和厭氧菌的蛋白合成。
Bacterial
PNU-176798 is an antimicrobial agent, with a minimum inhibitory concentration (MIC) of 1.4 μM for E. coli . PNU-176798 inhibits fMet-tRNA binding to the 70S ribosomes, with an IC 50 of 32 μM. PNU-176798 also blocks translation, 70S initiation with IC 50 s of 0.53, and 32 μM, respectively. PNU-176798 inhibits peptidyl transferase (IC 50 , 40 μM), and the inhibition is more pronounced in the presence of elongation factor P (EF-P). PNU-176798 markedly inhibits the EF-G-mediated translocation of fMet-tRNA (IC 50 , 8 μM).