CP-96021 HYDROCHLORIDE
| 中文名稱 | CP-96021 HYDROCHLORIDE |
|---|---|
| 中文同義詞 | 化合物 T10872;化合物 CP-96021 HYDROCHLORIDE |
| 英文名稱 | CP-96021 hydrochloride |
| 英文同義詞 | CP-96021 hydrochloride;CP96021 hydrochloride,CP 96021 hydrochloride |
| CAS號(hào) | 167011-22-5 |
| 分子式 | C29H22ClFN4OS |
| 分子量 | 529.03 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 167011-22-5.mol |
| 結(jié)構(gòu)式 |  |
CP-96021 HYDROCHLORIDE 性質(zhì)
CP-96021 hydrochloride 是一種平衡，有效的口服活性白三烯 D4 (LTD4)/血小板活化因子 (PAF) 受體拮抗劑，Ki 值分別為 34 nM 和 37 nM。
|
LTC 4 34 nM (Ki) |
Platelet activating factor (PAF) receptor 37 nM (Ki) |
In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED 50 s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED 50 s of 1.8 mg/kg p.o.