醋酸蘭瑞肽
| 中文名稱 | 醋酸蘭瑞肽 |
|---|---|
| 中文同義詞 | 化合物LANREOTIDE ACETATE;化合物LANREOTIDE ACETATE,10 MM DMSO 溶液;Lanreotide acetate :醋酸蘭瑞肽, 醋酸血管肽;Lanreotide acetate :醋酸蘭瑞肽, 醋酸血管肽;醋酸蘭瑞肽 |
| 英文名稱 | Lanreotide acetate |
| 英文同義詞 | BIM 23014 (acetate);Lanreotide,Lanreotide acetate,inhibit,hormone,apoptosis,pituitary,BIM23014,Inhibitor,BIM-23014,GH3 cells,tumor,adenoma,GH-secreting,BIM 23014;Lanreotide acetate, 10 mM in DMSO |
| CAS號 | 2378114-72-6 |
| 分子式 | C56H73N11O12S2 |
| 分子量 | 1156.39 |
| EINECS號 | |
| 相關類別 | 多肽 |
| Mol文件 | 2378114-72-6.mol |
| 結構式 |  |
醋酸蘭瑞肽 性質
| 形態(tài) | 固體 |
|---|---|
| 顏色 | 白色至米白色 |
| 序列 | {d-2nal}-Cys-Tyr-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7) |
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate 是一種天然生長抑素肽的類似物，是生長激素 growth hormone (GH)的生理抑制劑。Lanreotide 也具有抗腫瘤作用。
Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100? nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion.
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000?nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57?nM.
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro.
Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition.
| Animal Model: | Male nude mice, 8 weeks old and 20–25?g in body weight (GH3 tumor-bearing nude mice) |
| Dosage: | 2.5, 5, 10?mg/kg |
| Administration: | Subcutaneous; daily for 5 days |
| Result: | Produced tumor growth inhibition. |
安全信息
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 5mg | 892.93元 |
| 2026/07/06 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 25mg | 2678.21元 |