ZONIPORIDE HYDROCHLORIDE HYDRATE
| 中文名稱 | ZONIPORIDE HYDROCHLORIDE HYDRATE |
|---|---|
| 中文同義詞 | 化合物 T13413;化合物 ZONIPORIDE HYDROCHLORIDE HYDRATE |
| 英文名稱 | Zoniporide hydrochloride hydrate |
| 英文同義詞 | CP-597396 hydrochloride hydrate |
| CAS號(hào) | 863406-85-3 |
| 分子式 | C17H19ClN6O2 |
| 分子量 | 374.83 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 863406-85-3.mol |
| 結(jié)構(gòu)式 |  |
ZONIPORIDE HYDROCHLORIDE HYDRATE 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
Zoniporide (CP-597396) hydrochloride hydrate 是 1 型鈉氫交換劑 (NHE-1) 的有效和選擇性抑制劑。Zoniporide hydrochloride hydrate 抑制人 NHE-1 (IC50=14 nM)，與其他 NHE 亞型相比具有大于 150 倍的選擇性，并有效抑制離體 NHE-1 依賴性的人血小板溶脹 (IC50=59 nM)。
IC50: 14 nM (NHE-1)
Zoniporide hydrochloride hydrate (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED
50
=0.45 mg/kg/h) in open chest anesthetized rabbits.
Zoniporide exhibits moderate plasma protein binding, has a t
1/2
of 1.5 hours in monkeys, and has one major active metabolite.
Zoniporide hydrochloride hydrate treatment shows the AUC
0-∞
and t
1/2
are 0.07 μg h/mL and 0.5 hours, respectively.
| Animal Model: | Rabbit |
| Dosage: | 0.25, 1, 4 mg/kg |
| Administration: | Every hour for 2 hours; intravenous injection |
| Result: | Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED 50 was 0.45 mg/kg/h. |
| Animal Model: | Rat |
| Dosage: | 1 mg/kg |
| Administration: | Intravenous injection(Pharmacokinetic Analysis) |
| Result: | The AUC 0-∞ and t 1/2 were 0.07 μg h/mL and 0.5 hours, respectively. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-105064D | ZONIPORIDE HYDROCHLORIDE HYDRATE Zoniporide hydrochloride hydrate | 863406-85-3 | 1 mg | 800元 |
| 2026/06/05 | HY-105064D | ZONIPORIDE HYDROCHLORIDE HYDRATE Zoniporide hydrochloride hydrate | 863406-85-3 | 5 mg | 1690元 |