4-[3-CYCLOPROPYL-5-METHYL-1-(METHYLSULFONYLMETHYL)PYRAZOL-4-YL]OXY-2,6-DIMETHYLBENZONITRILE
概述 用途與合成方法 MSDS 4-[3-CYCLOPROPYL-5-METHYL-1-(METHYLSULFONYLMETHYL)PYRAZOL-4-YL]OXY-2,6-DIMETHYLBENZONITRILE價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱 | 4-[3-CYCLOPROPYL-5-METHYL-1-(METHYLSULFONYLMETHYL)PYRAZOL-4-YL]OXY-2,6-DIMETHYLBENZONITRILE |
|---|---|
| 中文同義詞 | 化合物 T28362;化合物PF-02413873;化合物PF-02413873,10 MM DMSO 溶液 |
| 英文名稱 | PF-2413873 |
| 英文同義詞 | PF-2413873;4-((3-cyclopropyl-5-methyl-1-((methylsulfonyl)methyl)-1H-pyrazol-4-yl)oxy)-2,6-dimethylbenzonitrile;4-[3-cyclopropyl-5-methyl-1-(methylsulfonylmethyl)pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile;nonsteroidal,inhibit,PF 2413873,Progesterone Receptor,endometrial,PF-2413873,nuclear,PF 02413873,NR3C3,PF2413873,PF-02413873,translocation,progesterone,Inhibitor;Benzonitrile, 4-[[3-cyclopropyl-5-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl-;PF-02413873, 10 mM in DMSO |
| CAS號(hào) | 936345-35-6 |
| 分子式 | C18H21N3O3S |
| 分子量 | 359.44 |
| EINECS號(hào) | |
| 相關(guān)類別 | 制劑-拮抗劑 |
| Mol文件 | 936345-35-6.mol |
| 結(jié)構(gòu)式 | ![4-[3-CYCLOPROPYL-5-METHYL-1-(METHYLSULFONYLMETHYL)PYRAZOL-4-YL]OXY-2,6-DIMETHYLBENZONITRILE 結(jié)構(gòu)式](CAS/20210111/GIF/936345-35-6.gif) |
4-[3-CYCLOPROPYL-5-METHYL-1-(METHYLSULFONYLMETHYL)PYRAZOL-4-YL]OXY-2,6-DIMETHYLBENZONITRILE 性質(zhì)
| 熔點(diǎn) | 163-164 °C |
|---|---|
| 沸點(diǎn) | 548.9±50.0 °C(Predicted) |
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | room temp |
| 溶解度 | DMSO：100 mg/mL（278.21 mM；需要超聲波） |
| 酸度系數(shù)(pKa) | 1.12±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至淺黃色 |
| InChI | 1S/C18H21N3O3S/c1-11-7-15(8-12(2)16(11)9-19)24-18-13(3)21(10-25(4,22)23)20-17(18)14-5-6-14/h7-8,14H,5-6,10H2,1-4H3 |
| InChIKey | QSFGZNVRVZHUGV-UHFFFAOYSA-N |
| SMILES | CC1=C(C#N)C(C)=CC(OC2=C(C)N(CS(=O)(C)=O)N=C2C3CC3)=C1 |
PF-02413873 (PF-2413873) 是一種有效的、選擇性、完全競(jìng)爭(zhēng)性和口服活性的非甾體孕酮受體 (PR) 拮抗劑，Ki 值為 2.6 nM。PF-02413873 可以阻斷孕激素結(jié)合和 PR 核易位，并在體內(nèi)抑制子宮內(nèi)膜的生長(zhǎng)。
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-11028 | 4-[3-CYCLOPROPYL-5-METHYL-1-(METHYLSULFONYLMETHYL)PYRAZOL-4-YL]OXY-2,6-DIMETHYLBENZONITRILE PF-02413873 | 936345-35-6 | 1 mg | 411元 |
| 2026/06/05 | HY-11028 | 4-[3-CYCLOPROPYL-5-METHYL-1-(METHYLSULFONYLMETHYL)PYRAZOL-4-YL]OXY-2,6-DIMETHYLBENZONITRILE PF-02413873 | 936345-35-6 | 5 mg | 950元 |