阿地米屈
| 中文名稱 | 阿地米屈 |
|---|---|
| 中文同義詞 | N1,N9-雙(2-羥乙基)壬二酰胺;阿地米屈;阿地米屈,10 MM DMSO 溶液;ADIM屈 |
| 英文名稱 | Adelmidrol |
| 英文同義詞 | N,N'-Bis(2-hydroxyethyl)nonanediamide;NSC 27132;Nonanediamide, N1,N9-bis(2-hydroxyethyl)-;AdelMitrol USP/EP/BP;N1,N9-bis(2-hydroxyethyl)-nonanediamide;China biggest manufacturer,AdelMitrol,1675-66-7;Demiqu;NF-κB,Nuclear factor-kappaB,PPAR,COX,Adelmidrol,Cyclooxygenase,Peroxisome proliferator-activated receptors,inhibit,Inhibitor,Nuclear factor-κB |
| CAS號 | 1675-66-7 |
| 分子式 | C13H26N2O4 |
| 分子量 | 274.36 |
| EINECS號 | |
| 相關類別 | 食品添加劑 |
| Mol文件 | 1675-66-7.mol |
| 結構式 |  |
阿地米屈 性質
| 熔點 | 132-134℃ |
|---|---|
| 沸點 | 596.4±45.0 °C(Predicted) |
| 密度 | 1.097±0.06 g/cm3(Predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | DMSO:77.5(最大濃度 mg/mL);282.47(最大濃度 mM) 乙醇:28.0(最大濃度 mg/mL);102.06(最大濃度 mM) 水:55.0(最大濃度 mg/mL);200.47(最大濃度 mM) |
| 酸度系數(pKa) | 14.19±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| InChI | InChI=1S/C13H26N2O4/c16-10-8-14-12(18)6-4-2-1-3-5-7-13(19)15-9-11-17/h16-17H,1-11H2,(H,14,18)(H,15,19) |
| InChIKey | PAHZPHDAJQIETD-UHFFFAOYSA-N |
| SMILES | C(NCCO)(=O)CCCCCCCC(NCCO)=O |
|
NF-κB
|
COX-2
|
PPARγ
|
Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colon.
Adelmidrol (10 mg/kg, o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury. Moreover, 4 days after colitis induced by dinitrobenzene sulfonic acid (DNBS) treatment, all mice have diarrhea and a reduction in body weight (compared with the sham groups). Adelmidrol (10 mg/kg, o.s.) treatment significantly reduces the loss of body weight. The inflammatory bowel disease (IBD) induced by DNBS intrarectally administered is also characterized by an augmentation in myeloperoxidase (MPO) activity, an indicator of neutrophil accumulating in the colon. This is consistent with light microscopic observations showing the colon of vehicle-treated DNBS mice to contain a large number of neutrophils. In contrast, Adelmidrol (10 mg/kg, o.s.) significantly reduces the degree of polymorphonuclear cell infiltration (determined as reduction in MPO activity) in inflamed colon.