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863598-09-8

863598-09-8

中文名稱863598-09-8
中文同義詞化合物CASEIN KINASE II INHIBITOR IV;3-(3-(2-((3,4,5-三甲氧基苯基)氨基)-7H-吡咯[2,3-D]嘧啶-7-基)苯基)丙腈;化合物CASEIN KINASE II INHIBITOR IV,10 MM DMSO 溶液;CASEIN KINASE II INHIBITOR IV |CAS 863598-09-8;角質(zhì)形成細(xì)胞分化誘導(dǎo)劑
英文名稱Casein Kinase II Inhibitor IV
英文同義詞Casein Kinase II Inhibitor IV;CK2-IN-1;Benzenepropanenitrile, 3-[2-[(3,4,5-trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-;3-[2-[(3,4,5-Trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzenepropanenitrile;3-(3-(2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propanenitrile;Inhibitor,Casein Kinase,Casein Kinase II Inhibitor IV,inhibit;Keratinocyte Differentiation Inducer;3-(3-(2-((3,4,5-Trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propanenitrile , Casein Kinase II Inhibitor IV
CAS號(hào)863598-09-8
分子式C24H23N5O3
分子量429.47
EINECS號(hào)
相關(guān)類別
Mol文件863598-09-8.mol
結(jié)構(gòu)式863598-09-8 結(jié)構(gòu)式

863598-09-8 性質(zhì)

沸點(diǎn)605.0±65.0 °C(Predicted)
密度1.25±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at -20°C
溶解度二甲基亞砜:≥250 mg/ml(582.11mM)
酸度系數(shù)(pKa)6.44±0.30(Predicted)
形態(tài)固體
顏色淺黃至黃色

863598-09-8 用途與合成方法

Casein Kinase II Inhibitor IV是表皮角質(zhì)形成細(xì)胞分化的小分子誘導(dǎo)劑。

Target: Casein Kinase

Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes.

安全信息

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-111378Casein Kinase II Inhibitor IV863598-09-81 mg748元
2026/06/05HY-111378863598-09-8
Casein Kinase II Inhibitor IV
863598-09-85mg2163元

863598-09-8 上下游產(chǎn)品信息

"863598-09-8"相關(guān)產(chǎn)品信息
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