隱陡頭菌素M
| 中文名稱 | 隱陡頭菌素M |
|---|---|
| 中文同義詞 | 隱陡頭菌素M;伊魯丁M |
| 英文名稱 | illudin M |
| 英文同義詞 | illudin M;(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1'-cyclopropan]-7(6H)-one;(3'S,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one;Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3'S,6'R)-;(3'S,6'R)-3',6'-dihydroxy-2',2',4',6'-tetramethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one |
| CAS號 | 1146-04-9 |
| 分子式 | C15H20O3 |
| 分子量 | 248.32 |
| EINECS號 | |
| 相關(guān)類別 | ADC |
| Mol文件 | 1146-04-9.mol |
| 結(jié)構(gòu)式 |  |
隱陡頭菌素M 性質(zhì)
| 熔點(diǎn) | 120-122.5° (Matsumoto); mp 128-130° (McMorris) |
|---|---|
| 沸點(diǎn) | 452.4±45.0 °C(Predicted) |
| 密度 | 1.24±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | DMF：可溶； DMSO：可溶；乙醇：可溶；甲醇：可溶 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 12.57±0.70(Predicted) |
| 顏色 | 米白色至淺黃色 |
| InChI | InChI=1S/C15H20O3/c1-8-10-9(7-13(2,3)12(10)17)11(16)14(4,18)15(8)5-6-15/h7,12,17-18H,5-6H2,1-4H3/t12-,14+/m1/s1 |
| InChIKey | QVMDIQLUNODCTG-OCCSQVGLSA-N |
| SMILES | C12([C@](O)(C)C(=O)C3C(=C1C)[C@@H](O)C(C)(C)C=3)CC2 |
Illudin M 是一種細(xì)胞毒性真菌倍半萜，可以從 Omphalotus olearius 蘑菇培養(yǎng)基中分離得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗腫瘤活性。
Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro.
Apoptosis Analysis
| Cell Line: | Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) |
| Concentration: | 0.01 μM, 1 μM, 10 μM |
| Incubation Time: | 24 hours, 48 hours,72 hours, 96 hours, 120 hours |
| Result: | Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%). |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-122493 | 隱陡頭菌素M Illudin M | 1146-04-9 | 1mg | 4000元 |
| 2024/08/19 | HY-122493 | 隱陡頭菌素M Illudin M | 5 mg | 8400元 |