Ro 64-6198
| 中文名稱 | Ro 64-6198 |
|---|---|
| 中文同義詞 | 化合物 T16772;Ro 64-6198試劑;化合物:Ro 64-6198 CAS:280783-56-4;Ro 64-6198試劑;化合物:Ro 64-6198 CAS:280783-56-4;化合物 Ro 64-6198 |
| 英文名稱 | Ro 64-6198 |
| 英文同義詞 | Ro 64-6198;Ro 64-6198 >=98% (HPLC);1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl- |
| CAS號 | 280783-56-4 |
| 分子式 | C26H31N3O |
| 分子量 | 401.54 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 280783-56-4.mol |
| 結(jié)構(gòu)式 | ![]() |
Ro 64-6198 性質(zhì)
| 沸點(diǎn) | 626.2±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 15.03±0.20(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至黃色 |
| InChIKey | JLFMYEAXZNPWBK-REWPJTCUSA-N |
| SMILES | O=C1C2(CCN([C@]3([H])C4=CC=CC5=C4[C@](CCC5)([H])CC3)CC2)N(C6=CC=CC=C6)CN1 |
Nociceptin receptor
Ro 64-6198 also produces rapid desensitization of the NOP receptor. In vitro studies shows that treatment with Ro 64-6198 results in a functional desensitization of the receptor, a loss in binding sites, and an apparent decrease in binding affinity. The desensitization produced by Ro 64-6198 is not reversed by acidic washes.
Ro 64-6198 does recruit both arrestin3 (
EC
50
of 0.912 μM) and arrestin2 (
EC
50
of 1.20 μM) to the NOP receptor in a concentration-dependent manner comparably with N/OFQ.
At low doses Ro 64-6198 is anxiolytic in several neophobic tests, including the marble burying test in mice, the elevated plus maze in rats and the open field test in rats. In the marble burying test, at 1 mg/kg, i.p., Ro 64-6198 produces a decrease in the number of marbles buried, without altering locomotor activity, indicating a decrease in neophobia and anxiety. Ro 64-6198 selectively increases the number of open arm transitions and time spent in the open arms of the elevated plus maze at doses of 0.32-3 mg/kg, i.p., without affecting closed arm transitions or locomotor activity in the closed arms. In the open field test, Ro 64-6198, at doses of 0.32-3 mg/kg, attenuates the inhibition of exploration that results from the stress of a novel environment.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-12844 | Ro 64-6198 Ro 64-6198 | 280783-56-4 | 1mg | 900元 |
| 2026/06/05 | HY-12844 | Ro 64-6198 Ro 64-6198 | 280783-56-4 | 5mg | 2160元 |
