吖啶黃
| 中文名稱 | 吖啶黃 |
|---|---|
| 中文同義詞 | 丫啶黃素/吖啶黃素/吖啶黃/吖黃素/3,6-二氨基-10-甲基吖啶鹽酸鹽和3,6-二氨基吖啶混合物/吖啶素;吖啶黃素(3,6-二氨基-10-甲基吖啶鹽酸鹽和3,6-二氨基吖啶的混合;丫啶黃素;3,6-二氨基-10-甲基吖啶鹽酸鹽和3,6-二氨基吖啶混合物;吖啶黃素;吖啶黃素(3,6-二氨基-10-甲基吖啶鹽酸鹽和3,6-二氨基吖啶的混合物);吖啶素;吖啶黃素 |
| 英文名稱 | ACRIFLAVINE |
| 英文同義詞 | 2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE;Acriflavine 10;Trypaflavine Neutral;GUANOSINE ULTRA PURE GRADE;4-Acetamino phenol ( APAP );Acriflavine 〔Trypaflavine〕;XANTHACRIDINE;TRYPAFLAVINE FS |
| CAS號(hào) | 8048-52-0 |
| 分子式 | C27H25ClN6 |
| 分子量 | 468.98 |
| EINECS號(hào) | 999-999-2 |
| 相關(guān)類別 | 試劑;生化試劑;熒光探針，標(biāo)記，顆粒和染色;生物化學(xué);各種化學(xué)試劑;色素類;生化試劑-色素類;化學(xué)試劑;marker;培養(yǎng)基配套試劑;合成材料中間體;化工原料;通用生化試劑-生物染色劑與化學(xué)指示劑;染色劑 |
| Mol文件 | 8048-52-0.mol |
| 結(jié)構(gòu)式 |  |
吖啶黃 性質(zhì)
| 熔點(diǎn) | 179-181 °C |
|---|---|
| 沸點(diǎn) | 612.69°C (rough estimate) |
| 密度 | 1.0933 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 在水中的溶解度為0.33g/mL(lit.)(lit.) |
| 形態(tài) | 粉末 |
| 顏色 | 深橙色至棕紅色 |
| 水溶解性 | H2O: 0.33g/mL (lit.)(lit.) |
| Merck | 14,123 |
| InChI | 1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H |
| InChIKey | PEJLNXHANOHNSU-UHFFFAOYSA-N |
| SMILES | C12C=C(N)C=CC1=CC1=CC=C(N)C=C1[N+]=2C.C12C=C(C=CC1=CC1=CC=C(N)C=C1N=2)N.[Cl-] |
| CAS 數(shù)據(jù)庫(kù) | 8048-52-0(CAS DataBase Reference) |
| EPA化學(xué)物質(zhì)信息 | Xanthacridinum (8048-52-0) |
Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells.
Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis.
安全信息
| 危險(xiǎn)品標(biāo)志 | Xn,N |
|---|---|
| 危險(xiǎn)類別碼 | 22-37/38-41-50/53-20/21/22-50-36/37/38 |
| 安全說明 | 26-39-60-61-36-37/39-29-36/37/39 |
| 危險(xiǎn)品運(yùn)輸編號(hào) | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS號(hào) | AR9660000 |
| 海關(guān)編碼 | 38249064 |
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 危險(xiǎn)性類別 | 急性毒性 類別4 經(jīng)口 危害水生環(huán)境-急性危害 類別1 眼部刺激 類別2 經(jīng)皮刺激 類別2 特異性靶器官毒性-一次接觸，類別3 |
| 提供商 | 語(yǔ)言 |
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