ACOLBIFENE
| 中文名稱 | ACOLBIFENE |
|---|---|
| 中文同義詞 | 化合物 T12654;阿考比芬,10 MM DMSO 溶液 |
| 英文名稱 | ACOLBIFENE |
| 英文同義詞 | 2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran;rac-Acolbifene;ACOLBIFENE;(Rac)-EM-652;2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-;(Rac)-Acolbifene, 10 mM in DMSO |
| CAS號(hào) | 151533-34-5 |
| 分子式 | C29H31NO4 |
| 分子量 | 457.56 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 151533-34-5.mol |
| 結(jié)構(gòu)式 |  |
ACOLBIFENE 性質(zhì)
| 沸點(diǎn) | 651.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.217±0.06 g/cm3(Predicted) |
| 溶解度 | 二甲基亞砜：100 mg/mL（218.55 mM） |
| 酸度系數(shù)(pKa) | 9.70±0.40(Predicted) |
| 形態(tài) | 晶體 |
| 顏色 | 紫至紫紅色 |
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) 是 EM652 (estrogen receptor 拮抗劑) 的外消旋形式，具有抗雌激素和雌激素活性。 (Rac)-Acolbifene (EM-343; (Rac)-EM-652) 含哌啶環(huán)，具有良好的藥理作用，RBA=380。
(Rac)-Acolbifene (EM-343; (Rac)-EM-652)? shows a inhibitory effect in T-47D cells with an IC 50 value of 0.110 nM.
Cell Viability Assay
| Cell Line: | T-47D cells |
| Concentration: | 0.110 nM |
| Incubation Time: | 72 hours |
| Result: | Inhibited T-47D cells growth. |
(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice).
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 5mg | 890元 |
| 2026/06/05 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 10mM * 1mLin DMSO | 896元 |