維甲酰酚胺
| 中文名稱 | 維甲酰酚胺 |
|---|---|
| 中文同義詞 | 維甲酰酚胺;芬維A胺;酚維A胺;全反式-N-(4-羥苯基)維甲酸;維甲酰酚胺FENRETINIDE;維甲酸對羥基苯胺;芬維A胺, >98%;結(jié)合珠蛋白相關(guān)蛋白抗體 |
| 英文名稱 | 4-HYDROXYPHENYLRETINAMIDE |
| 英文同義詞 | 4-HYDROXYPHENYLRETINAMIDE;4HPR;p-Hydroxyphenylretinamide;4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide;(2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide;Fenretinimide;Fenretinide(4-HPR);RetinaMide,N-(4-hydroxyphenyl)- |
| CAS號 | 65646-68-6 |
| 分子式 | C26H33NO2 |
| 分子量 | 391.55 |
| EINECS號 | 200-256-5 |
| 相關(guān)類別 | 小分子抑制劑;科研試劑;醫(yī)藥原料藥;蛋白酪氨酸激酶;小分子抑制劑，天然產(chǎn)物;對照品;中藥對照品;醫(yī)藥原料;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;Intracellular receptor;Drug Analogues;Inhibitors |
| Mol文件 | 65646-68-6.mol |
| 結(jié)構(gòu)式 |  |
維甲酰酚胺 性質(zhì)
| 熔點 | 162-163°C |
|---|---|
| 沸點 | 597.6±42.0 °C(Predicted) |
| 密度 | 1.081±0.06 g/cm3(Predicted) |
| 儲存條件 | -20°C |
| 溶解度 | 可溶于氯仿（少許）、甲醇（少許） |
| 形態(tài) | 橙色固體 |
| 酸度系數(shù)(pKa) | 9.98±0.26(Predicted) |
| 顏色 | 粘黃色 |
| 生物來源 | synthetic (organic) |
| 最大波長(λmax) | 362nm(MeOH)(lit.) |
| Merck | 14,3998 |
| 穩(wěn)定性 | 對光敏感，應(yīng)避光保存 |
| InChIKey | AKJHMTWEGVYYSE-FXILSDISSA-N |
| SMILES | C(NC1=CC=C(O)C=C1)(=O)/C=C(/C=C/C=C(/C=C/C1C(C)(C)CCCC=1C)\C)\C |
| CAS 數(shù)據(jù)庫 | 65646-68-6(CAS DataBase Reference) |
Fenretinide (4-HPR) exerts not just acute but also long term antitumor activity in selected T-ALL cell lines. Fenretinide inhibits DES activity in CCRF-CEM leukemia cells in a dose and time dependent manner, leading to a concomitant increase of the endogenous cellular dhCer content. Fenretinide (3 μM)-induced dhCer accumulation in both CCRF-CEM and Jurkat cells. Ceramide inhibition with fenretinide protects insulin signaling. Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake. Fenretinide inhibits OVCAR-5 cell proliferation and viability at concentrations higher than 1 microM, with 70-90% growth inhibition at 10 microM. Fenretinide (1 microM) significantly inhibits OVCAR-5 invasion after 3 days preincubation. Endothelial cells treated with 1 microM 4-HPR fails to form tubes, but forms small cellular aggregates.
Fenretinide (4-HPR) (10 mg/kg, i.p.) selectively inhibits ceramide accumulation HFD-fed male C57Bl/6 mice. Fenretinide treatment improves glucose tolerance and insulin sensitivity as determined by both glucose and insulin tolerance tests. Addition of 25 mg/kg ketoconazole to Fenretinide in NOD/SCID mice increased 4-HPR plasma levels.
安全信息
| 危險品標志 | T |
|---|---|
| 危險類別碼 | 60-61-20/21/22-36/37/38 |
| 安全說明 | 53-26-36/37/39-45-52 |
| WGK Germany | 3 |
| RTECS號 | VH6420000 |
| 海關(guān)編碼 | 2924297099 |
| 存儲類別 | 6.1C - 可燃，急性毒性 類別3 毒性化合物或者引起慢性影響的化合物 |
| 危險性類別 | 急性毒性 類別4 經(jīng)皮 急性毒性 類別4 吸入 急性毒性 類別4 經(jīng)口 眼部刺激 類別2 生殖毒性 類別1B 經(jīng)皮刺激 類別2 特異性靶器官毒性-一次接觸，類別3 |
| 提供商 | 語言 |
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英文
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-15373R | 維甲酰酚胺 Fenretinide (Standard) | 65646-68-6 | 5 mg | 704元 |
| 2026/06/05 | HY-15373R | 維甲酰酚胺 Fenretinide (Standard) | 65646-68-6 | 10 mg | 1056元 |