3-甲基亞磺酰丙基異硫氰酸酯
| 中文名稱 | 3-甲基亞磺酰丙基異硫氰酸酯 |
|---|---|
| 中文同義詞 | 3-甲基亞磺酰丙基異硫氰酸酯;化合物 T15544;化合物IBERIN |
| 英文名稱 | IBERIN |
| 英文同義詞 | IBERIN;1-isothiocyanato-3-(methylsulfinyl)propane;3-methylsulphinylpropylisothiocyanate;isothiocyanicacid,3-(methylsulfinyl)propylester;1-ISOTHIOCYANATO-3-(METHYLSULPHINYL)-PROPANE;3-(Methylsulfinyl)propyl isothiocyanate;Methyl(3-isothiocyanatopropyl) sulfoxide;3-methylsulfinylpropylimino(thioxo)methane |
| CAS號(hào) | 505-44-2 |
| 分子式 | C5H9NOS2 |
| 分子量 | 163.26 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 505-44-2.mol |
| 結(jié)構(gòu)式 | ![]() |
3-甲基亞磺酰丙基異硫氰酸酯 性質(zhì)
| 沸點(diǎn) | 240.37°C (rough estimate) |
|---|---|
| 密度 | 1.142 (estimate) |
| 折射率 | 1.5237 (estimate) |
| 儲(chǔ)存條件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | 可溶于氯仿(少許)、甲醇(少許) |
| 形態(tài) | 油狀 |
| 顏色 | 無色 |
| 穩(wěn)定性 | 濕氣敏感 |
| InChIKey | LELAOEBVZLPXAZ-UHFFFAOYSA-N |
| SMILES | [S](=O)(CCCN=C=S)C |
|
Human Endogenous Metabolite
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Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9.
Iberin is tested in an in vivo foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 6.1C - 可燃,急性毒性 類別3 毒性化合物或者引起慢性影響的化合物 |
| 危險(xiǎn)性類別 | 急性毒性 類別3 經(jīng)皮 急性毒性 類別3 吸入 急性毒性 類別3經(jīng)口 危害水生環(huán)境-急性危害 類別1 危害水生環(huán)境-長期危害 類別1 眼部刺激 類別2 經(jīng)皮刺激 類別2 特異性靶器官毒性-一次接觸,類別3 |
