占托西林
| 中文名稱 | 占托西林 |
|---|---|
| 中文同義詞 | 占托西林;青黴黃素X;黃青霉素;化合物 T17261 |
| 英文名稱 | Xantocillin |
| 英文同義詞 | XANTHOCILLINX;XANTHOCILINX;Xantocillin;4,4'-(2,3-Diisocyano-1,3-butadiene-1,4-diyl)bisphenol;1,4-Di-p-oxyphenyl-2,3-di-isonitrilo-1,3-butadien;Brevicid;Brevicide;Brevicide-x |
| CAS號 | 580-74-5 |
| 分子式 | C18H12N2O2 |
| 分子量 | 0 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 580-74-5.mol |
| 結構式 |  |
占托西林 性質
| 沸點 | 430.53°C (rough estimate) |
|---|---|
| 密度 | 1.2396 (rough estimate) |
| 折射率 | 1.5800 (estimate) |
Xanthocillin 是從青霉中提取的一種海洋藥劑，通過抑制 MEK/ERK 途徑誘導自噬。
Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 μM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC
50
of 22.88 ± 4.76 μM.
Xantocillin (SD118-xanthocillin X (1)) (24.3 μM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1.
Cell Proliferation Assay
| Cell Line: | HepG2 cells |
| Concentration: | 6.9 μM, 13.89 μM, 27.78 μM, 55.56 μM |
| Incubation Time: | 48 hours |
| Result: | A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC 50 of 22.88 ± 4.76 μM. |
Western Blot Analysis
| Cell Line: | HepG2 cells |
| Concentration: | 24.3 μM |
| Incubation Time: | 12 hours, 24 hours, 48 hours |
| Result: | Increased the expression of the autophagy-related genes, LC3, and Beclin 1. |